ArticlePLoS computational biology2015
An Emerging Allee Effect Is Critical for Tumor Initiation and Persistence.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Characterizing Tumor Cell Movement in Partial Differential Equation Models of Triple-Negative Breast Cancer Receiving Neoadjuvant Therapy.Annals of biomedical engineering · 2026Article
- When effective anticancer therapies are, in fact, destabilizing the tumor's Group Phenotypic Composition.NPJ precision oncology · 2026Review
- Go-or-grow models in biology: a monster on a leash.Journal of mathematical biology · 2025Review
- Cancer model with moving extinction threshold reproduces real cancer data.Journal of the Royal Society, Interface · 2025Article
- Deep learning identifies heterogeneous subpopulations in breast cancer cell lines.npj biomedical innovations · 2025Article
- A Mathematical Perspective on the Influence of Allee Effects in Oncolytic Virotherapy.Mathematics (Basel, Switzerland) · 2025Article
- Advancing cancer drug development with mechanistic mathematical modeling: bridging the gap between theory and practice.Journal of pharmacokinetics and pharmacodynamics · 2024Review
- Evolution of phenotypic plasticity leads to tumor heterogeneity with implications for therapy.PLoS computational biology · 2024Article
- Mathematical modeling of intratumoral immunotherapy yields strategies to improve the treatment outcomes.PLoS computational biology · 2023Article
- Clonal cooperation through soluble metabolite exchange facilitates metastatic outgrowth by modulating Allee effect.Science advances · 2023Article
- Modeling the Role of Immune Cell Conversion in the Tumor-Immune Microenvironment.Bulletin of mathematical biology · 2023Article
- Data driven model discovery and interpretation for CAR T-cell killing using sparse identification and latent variables.Frontiers in immunology · 2023Article
- Model-informed experimental design recommendations for distinguishing intrinsic and acquired targeted therapeutic resistance in head and neck cancer.NPJ systems biology and applications · 2022Article
- Roadmap on plasticity and epigenetics in cancer.Physical biology · 2022Review
- Modelling glioma progression, mass effect and intracranial pressure in patient anatomy.Journal of the Royal Society, Interface · 2022Article
- Autocrine signaling can explain the emergence of Allee effects in cancer cell populations.PLoS computational biology · 2022Article
- BIO-LGCA: A cellular automaton modelling class for analysing collective cell migration.PLoS computational biology · 2021Article
- Group phenotypic composition in cancer.eLife · 2021Review
- Novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy.NPJ breast cancer · 2021Review
- Integrating evolutionary dynamics into cancer therapy.Nature reviews. Clinical oncology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor cells develop different strategies to cope with changing microenvironmental conditions. A prominent example is the adaptive phenotypic switching between cell migration and proliferation. While it has been shown that the migration-proliferation plasticity influences tumor spread, it remains unclear how this particular phenotypic plasticity affects overall tumor growth, in particular initiation and persistence. To address this problem, we formulate and study a mathematical model of spatio-temporal tumor dynamics which incorporates the microenvironmental influence through a local cell density dependence. Our analysis reveals that two dynamic regimes can be distinguished. If cell motility is allowed to increase with local cell density, any tumor cell population will persist in time, irrespective of its initial size. On the contrary, if cell motility is assumed to decrease with respect to local cell density, any tumor population below a certain size threshold will eventually extinguish, a fact usually termed as Allee effect in ecology. These results suggest that strategies aimed at modulating migration are worth to be explored as alternatives to those mainly focused at keeping tumor proliferation under control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.