ArticlePLoS computational biology2015
Relating Alpha Power and Phase to Population Firing and Hemodynamic Activity Using a Thalamo-cortical Neural Mass Model.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 57 citations in OpenAlex.
- Alpha-tACS Improves Executive Function and Alpha Power Spectral Density in Patients With Post-Stroke Cognitive Impairment.CNS neuroscience & therapeutics · 2026Trial
- The alpha rhythm: from physiology to behavior.Physiological reviews · 2026Review
- Lifespan development of EEG alpha and aperiodic component sources is shaped by the connectome and axonal delays.National science review · 2026Article
- Higher baseline alpha power is associated with faster responses in visual search.bioRxiv : the preprint server for biology · 2025Article
- Investigating the neurovascular coupling across multiple motor execution and imagery conditions: a whole-brain EEG-informed fMRI analysis.NeuroImage · 2025Article
- Resting-State EEG Oscillations in Amyotrophic Lateral Sclerosis (ALS): Toward Mechanistic Insights and Clinical Markers.Journal of clinical medicine · 2025Review
- Revealing excitation-inhibition imbalance in Alzheimer's disease using multiscale neural model inversion of resting-state functional MRI.Communications medicine · 2025Article
- Article
- Alpha rhythm slowing in temporal lobe epilepsy across scalp EEG and MEG.Brain communications · 2024Article
- Beyond pulsed inhibition: Alpha oscillations modulate attenuation and amplification of neural activity in the awake resting state.Cell reports · 2023Article
- Neural Synchrony and Network Dynamics in Social Interaction: A Hyper-Brain Cell Assembly Hypothesis.Frontiers in human neuroscience · 2022Article
- A Two-Person Neuroscience Approach for Social Anxiety: A Paradigm With Interbrain Synchrony and Neurofeedback.Frontiers in psychology · 2021Review
- Multiscale neural modeling of resting-state fMRI reveals executive-limbic malfunction as a core mechanism in major depressive disorder.NeuroImage. Clinical · 2021Article
- Prisoners of Addictive Cues: Biobehavioral Markers of Overweight and Obese Adults with Food Addiction.Nutrients · 2020Article
- Article
- The role that choice of model plays in predictions for epilepsy surgery.Scientific reports · 2019Article
- Identification of Abnormal Circuit Dynamics in Major Depressive Disorder via Multiscale Neural Modeling of Resting-State fMRI.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2019Article
- Analytically determining frequency and amplitude of spontaneous alpha oscillation in Jansen's neural mass model using the describing function method.Chinese physics B = Zhongguo wu li B · 2018Article
- Classifying dynamic transitions in high dimensional neural mass models: A random forest approach.PLoS computational biology · 2018Article
- A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks.PLoS computational biology · 2018Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oscillations are ubiquitous phenomena in the animal and human brain. Among them, the alpha rhythm in human EEG is one of the most prominent examples. However, its precise mechanisms of generation are still poorly understood. It was mainly this lack of knowledge that motivated a number of simultaneous electroencephalography (EEG) - functional magnetic resonance imaging (fMRI) studies. This approach revealed how oscillatory neuronal signatures such as the alpha rhythm are paralleled by changes of the blood oxygenation level dependent (BOLD) signal. Several such studies revealed a negative correlation between the alpha rhythm and the hemodynamic BOLD signal in visual cortex and a positive correlation in the thalamus. In this study we explore the potential generative mechanisms that lead to those observations. We use a bursting capable Stefanescu-Jirsa 3D (SJ3D) neural-mass model that reproduces a wide repertoire of prominent features of local neuronal-population dynamics. We construct a thalamo-cortical network of coupled SJ3D nodes considering excitatory and inhibitory directed connections. The model suggests that an inverse correlation between cortical multi-unit activity, i.e. the firing of neuronal populations, and narrow band local field potential oscillations in the alpha band underlies the empirically observed negative correlation between alpha-rhythm power and fMRI signal in visual cortex. Furthermore the model suggests that the interplay between tonic and bursting mode in thalamus and cortex is critical for this relation. This demonstrates how biophysically meaningful modelling can generate precise and testable hypotheses about the underpinnings of large-scale neuroimaging signals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.