ArticleJournal of acquired immune deficiency syndromes (1999)2016
Antiretroviral Regimen Durability and Success in Treatment-Naive and Treatment-Experienced Patients by Year of Treatment Initiation, United States, 1996-2011.
Article in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Rilpivirine use in the Swiss HIV cohort study: a prospective cohort study.BMC infectious diseases · 2017Trial
- Metabolomics of HIV in the Modern cART Era.Advances in experimental medicine and biology · 2026Review
- Trends in viral load suppression among HIV patients on antiretroviral therapy (ART) at Asante Mampong Municipal Hospital, Ghana: 2019-2023.BMC infectious diseases · 2024Article
- INSTI-Based Initial Antiretroviral Therapy in Adults with HIV, the HIV Outpatient Study, 2007-2018.AIDS research and human retroviruses · 2021Article
- Trends and factors associated with modification or discontinuation of the initial antiretroviral regimen during the first year of treatment in the Turkish HIV-TR Cohort, 2011-2017.AIDS research and therapy · 2021Article
- Substantial decline in heavily treated therapy-experienced persons with HIV with limited antiretroviral treatment options.AIDS (London, England) · 2020Article
- Treatment modification after starting cART in people living with HIV: retrospective analysis of the German ClinSurv HIV Cohort 2005-2017.Infection · 2020Article
- Patient-Reported Outcomes in an Observational Cohort of HIV-1-Infected Adults on Darunavir/Cobicistat-Based Regimens: Beyond Viral Suppression.The patient · 2020Article
- The HIV Outpatient Study-25 Years of HIV Patient Care and Epidemiologic Research.Open forum infectious diseases · 2020Review
- Mortality from suicide among people living with HIV and the general Swiss population: 1988-2017.Journal of the International AIDS Society · 2019Article
- Time spent with HIV viral load above 1500 copies/ml among patients in HIV care, 2000-2014.AIDS (London, England) · 2018Observational
- Room for Improvement: The HIV-Diabetes Care Continuum Over 15 Years in the Women's Interagency HIV Study.Open forum infectious diseases · 2018Article
- Trends in antiretroviral therapy prescription, durability and modification: new drugs, more changes, but less failure.AIDS (London, England) · 2018Article
- Increased Persistence of Initial Treatment for HIV Infection With Modern Antiretroviral Therapy.Journal of acquired immune deficiency syndromes (1999) · 2017Observational
- Durability of viral suppression with first-line antiretroviral therapy in patients with HIV in the UK: an observational cohort study.The lancet. HIV · 2017Observational
- Antiretroviral therapy initiation within seven days of enrolment: outcomes and time to undetectable viral load among children at an urban HIV clinic in Uganda.BMC infectious diseases · 2017Article
- HIV drug therapy duration; a Swedish real world nationwide cohort study on InfCareHIV 2009-2014.PloS one · 2017Observational
- Cost considerations in the current antiretroviral era.AIDS (London, England) · 2016Observational
- Association of HIV/AIDS Clinician Warm Line Utilization with Diagnosis and Management of Antiretroviral Treatment Failure in Mozambique: A Retrospective Analysis of Program Data.Journal of the International Association of Providers of AIDS CareArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAlthough modern combination antiretroviral therapy (cART) regimens are better tolerated and less complex than earlier treatments, regimen modification or discontinuation remains a concern.
methodsWe studied HIV Outpatient Study (HOPS) participants who initiated the first or second cART regimens during: 1996-1999, 2000-2003, 2004-2007, and 2008-2011. We analyzed regimen durability (time to regimen modification) and success (achieving undetectable plasma HIV RNA) for the first and second cART regimens using Kaplan-Meier curves and log-rank tests, and examined factors associated with durability and success of the first cART regimen using proportional hazards models.
resultsDurability of cART was progressively longer for cART regimens initiated in more recent periods: median first cART regimen durations were 1.0, 1.1, 2.1, and 4.6 years in 1996-1999, 2000-2003, 2004-2007, and 2008-2011, and the median second cART durations were 0.9, 1.2, 2.8, and 3.9 years, respectively (both P < 0.001). Comparing 1996-1999 and 2008-2011, the percentage of patients who achieved an undetectable HIV RNA within 6 months of first cART initiation increased from 65% to 81% and from 63% to 80% on second cART (both P < 0.001). Among patients initiating first cART during 2008-2011, black non-Hispanic/Latino race/ethnicity and ≥ twice-daily dosing were significantly associated with higher rates of regimen modification (P < 0.05), and higher baseline HIV RNA levels were associated with failure to achieve an undetectable HIV RNA (P < 0.001).
conclusionsAmong HIV-infected U.S. adults in routine HIV care, durability of the first and second cART regimens and the likelihood of prompt virological suppression increased during 1996-2011, coincident with the availability of more tolerable, less complex cART options.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.