ArticleBMC pulmonary medicine2015
Different KCO and VA combinations exist for the same DLCO value in patients with diffuse parenchymal lung diseases.
Article in BMC pulmonary medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Can Artificial Intelligence Interpret Pulmonary Function Tests and Predict Prolonged Air Leaks After Lung Resection.Cancers · 2026Article
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- Follistatin-respiratory connection predicting all-cause mortality among community-dwelling middle-to-old age individuals: Results from the I-Lan Longitudinal Study.The journal of nutrition, health & aging · 2024Article
- Late-onset pulmonary complications following allogeneic hematopoietic cell transplantation in pediatric patients: a prospective multicenter study.Bone marrow transplantation · 2024Article
- Automated airway quantification associates with mortality in idiopathic pulmonary fibrosis.European radiology · 2023Observational
- Review
- Prevalence and impact of airway diseases on clinical outcomes in idiopathic pulmonary fibrosis.The Korean journal of internal medicine · 2022Article
- Respiratory Impedance is Associated with Ventilation and Diffusing Capacity in Patients with Idiopathic Pulmonary Fibrosis Combined with Emphysema.International journal of chronic obstructive pulmonary disease · 2022Article
- Original Article: Clinical Research.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2021Article
- Functional parameters of small airways can guide bronchodilator use in idiopathic pulmonary fibrosis.Scientific reports · 2020Article
- Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis.ERJ open research · 2020Article
- Physiology of the lung in idiopathic pulmonary fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2018Review
- Debunking myths in pulmonary function testing.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2017Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDLCO is the product of the CO transfer coefficient (KCO) by the "accessible" alveolar volume (VA). In theory, the same DLCO may result from various combinations of KCO and VA values, each of which reflect different injury sites and mechanisms. We sought to determine in this study the potential variability of both VA and KCO for fixed values of DLCO in diffuse parenchymal lung diseases (DPLD).
methodsTo this end, we designed a retrospective, cross-sectional study of three distinct types of DPLD and analysed pulmonary function test (PFT) datasets.
resultsWe show here that for the same value of DLCO (50% predicted), KCO varied from 60 to 95% predicted and VA from 55 to 85% predicted in various types of DPLD idiopathic pulmonary fibrosis, sarcoidosis and connective tissue disease-associated DPLD, indicating distinct pathogenic mechanisms in these diseases. In addition, a comparison of VA with total lung capacity may help to evidence the distal airway obstruction sometimes associated with certain DPLD particularly sarcoidosis.
conclusionClinicians should take into account not only DLCO but also VA and KCO values when managing patients with DPLD.
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