Evidence map›Paper›PMID 26334567›Full record

ReviewLife sciences2015

Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis.

Satya Narayan, Ritika Sharma

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Life sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Molecular editing ofRSC medicinal chemistry · 2024
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Current and future biomarkers in colorectal cancer.Annals of gastroenterology · 2017
    Review
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Satya NarayanDepartment of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610 United States. Electronic address: snarayan@ufl.edu.
Ritika SharmaDepartment of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610 United States.
University of Florida · US

Funding

Tumor suppressor APC and breast carcinogenesis.R01CA100247 · NCI · UNIVERSITY OF FLORIDA · PI NARAYAN, SATYA · 2003 to 2007
$1.4M
Involvement of APC in DNA RepairR01CA097031 · NCI · UNIVERSITY OF FLORIDA · PI NARAYAN, SATYA · 2003 to 2006
$1.0M
NCI NIH HHS CA-097031NCI NIH HHS CA-100247NCI NIH HHS R01 CA097031NCI NIH HHS R01 CA100247
6 · The paper itself

Abstract

Colorectal cancer (CRC) is the third leading cause of death in both men and women in North America. Despite chemotherapeutic efforts, CRC is associated with a high degree of morbidity and mortality. Thus, to develop effective treatment strategies for CRC, one needs knowledge of the pathogenesis of cancer development and cancer resistance. It is suggested that colonic tumors or cell lines harbor truncated adenomatous polyposis coli (APC) without DNA repair inhibitory (DRI)-domain. It is also thought that the product of the APC gene can modulate base excision repair (BER) pathway through an interaction with DNA polymerase β (Pol-β) and flap endonuclease 1 (Fen-1) to mediate CRC cell apoptosis. The proposed therapy with temozolomide (TMZ) exploits this particular pathway; however, a high percentage of colorectal tumors continue to develop resistance to chemotherapy due to mismatch repair (MMR)-deficiency. In the present communication, we have comprehensively reviewed a critical issue that has not been addressed previously: a novel mechanism by which APC-induced blockage of single nucleotide (SN)- and long-patch (LP)-BER play role in DNA-alkylation damage-induced colorectal carcinogenesis.

Indexed as

DNA RepairAdenomatous Polyposis ColiAdenomatous Polyposis Coli ProteinAnimalsAntineoplastic AgentsCarcinogenesisColonDacarbazineDNA Polymerase betaFlap EndonucleasesHumansModels, MolecularMolecular Targeted TherapyMutationRectumTemozolomideAdenomatous Polyposis Coli ProteinAntineoplastic AgentsDacarbazineDNA Polymerase betaFlap EndonucleasesTemozolomideAdenomatous polyposis coliBase excision repairColorectal carcinogenesisDNA damage

Identifiers

PMID26334567
PMCPMC4604609
OpenAlexW2196342307

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.