ArticleEuropean radiology2016
Simultaneous visualization of tumour oxygenation, neovascularization and contrast agent perfusion by real-time three-dimensional optoacoustic tomography.
Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Evaluations of Oxygenation and Vascular Perfusion in Pre-Clinical Models of Cancer and Wound Healing Using OS-DCE OAI.Journal of visualized experiments : JoVE · 2026Article
- Evaluations of a Cutaneous Wound Healing Model Using Oxygen Enhanced - Dynamic Contrast Enhanced Photoacoustic Imaging (OE-DCE PAI).Molecular imaging and biology · 2024Article
- Fisheye piezo polymer detector for scanning optoacoustic angiography of experimental neoplasms.Photoacoustics · 2023Article
- Automatic force-controlled 3D photoacoustic system for human peripheral vascular imaging.Biomedical optics express · 2023Article
- Clinically translatable quantitative molecular photoacoustic imaging with liposome-encapsulated ICG J-aggregates.Nature communications · 2021Article
- Photoacoustic and high-frequency ultrasound imaging of systemic sclerosis patients.Arthritis research & therapy · 2021Article
- Spherical-view photoacoustic tomography for monitoringPhotoacoustics · 2020Article
- Brilliant cresyl blue enhanced optoacoustic imaging enables non-destructive imaging of mammalian ovarian follicles for artificial reproduction.Journal of the Royal Society, Interface · 2020Article
- Improving vascular imaging with co-planar mutually guided photoacoustic and diffuse optical tomography: a simulation study.Biomedical optics express · 2020Article
- Spatial heterogeneity of oxygenation and haemodynamics in breast cancer resolved in vivo by conical multispectral optoacoustic mesoscopy.Light, science & applications · 2020Article
- Longitudinal Photoacoustic Imaging of the Pharmacodynamic Effect of Vascular Targeted Therapy on Tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019Article
- Estimating blood oxygenation from photoacoustic images: can a simple linear spectroscopic inversion ever work?Journal of biomedical optics · 2019Article
- Concurrent fluorescence and volumetric optoacoustic tomography of nanoagent perfusion and bio-distribution in solid tumors.Biomedical optics express · 2019Article
- Listening to tissues with new light: recent technological advances in photoacoustic imaging.Journal of optics (2010) · 2019Article
- Real-time delay-multiply-and-sum beamforming with coherence factor forPhotoacoustics · 2019Article
- Rapid volumetric optoacoustic imaging of neural dynamics across the mouse brain.Nature biomedical engineering · 2019Article
- Raster-scan optoacoustic angiography of blood vessel development in colon cancer models.Photoacoustics · 2019Article
- Quantitative photoacoustic imaging study of tumours in vivo: Baseline variations in quantitative measurements.Photoacoustics · 2019Article
- Non-invasive determination of murine placental and foetal functional parameters with multispectral optoacoustic tomography.Light, science & applications · 2019Article
- Recent developments in multimodality fluorescence imaging probes.Acta pharmaceutica Sinica. B · 2018Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIntravital imaging within heterogenic solid tumours is important for understanding blood perfusion profiles responsible for establishment of multiple parameters within the tumour mass, such as hypoxic and nutrition gradients, cell viability, proliferation and drug response potentials.
methodsHerein, we developed a method based on a volumetric multispectral optoacoustic tomography (vMSOT) for cancer imaging in preclinical models and explored its capacity for three-dimensional imaging of anatomic, vascular and functional tumour profiles in real time.
resultsIn contrast to methods based on cross-sectional (2D) image acquisition as a basis for 3D rendering, vMSOT has attained concurrent observations from the entire tumour volume at 10 volumetric frames per second. This truly four dimensional imaging performance has enabled here the simultaneous assessment of blood oxygenation gradients and vascularization in solid breast tumours and revealed different types of blood perfusion profiles in-vivo.
conclusionThe newly introduced capacity for high-resolution three-dimensional tracking of fast tumour perfusion suggests vMSOT as a powerful method in preclinical cancer research and theranostics. As the imaging setup can be equally operated in both stationary and handheld mode, the solution is readily translatable for perfusion monitoring in a clinical setting. KEY POINTS: • vMSOT visualizes 3D anatomic, vascular and functional tumour profiles in real time. • Three types of blood perfusion profiles are revealed in breast tumour model. • The method is readily adaptable to operate in a handheld clinical mode.
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