ArticleJournal of pediatric gastroenterology and nutrition2016
Temporal Association Between Reflux-like Behaviors and Gastroesophageal Reflux in Preterm and Term Infants.
Article in Journal of pediatric gastroenterology and nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Safety of Proton Pump Inhibitor in Paediatrics: A Study Based on EudraVigilance Data.Fundamental & clinical pharmacology · 2025Article
- Combined multichannel intraluminal impedance and pH testing in infants and young children-a narrative review.Frontiers in pediatrics · 2025Review
- Prescriptions of anti-reflux drugs in neonatology and neonatal intensive care units: A large multicentre observational study (2014-2022).British journal of clinical pharmacology · 2024Observational
- Brief Resolved Unexplained Events Symptoms Frequently Result in Inappropriate Gastrointestinal Diagnoses and Treatment.The Journal of pediatrics · 2024Article
- Transpyloric Feed in Reflux-Associated Apnea in Preterm Newborns: A Prospective Study.HCA healthcare journal of medicine · 2023Article
- Neonatal gastroesophageal reflux.Early human development · 2022Article
- The Role of Combined Multichannel Intraluminal Impedance-pH Monitoring in Infants with Brief, Resolved, Unexplained Events.Pediatric gastroenterology, hepatology & nutrition · 2021Article
- Prolonging gavage feeds for reduction of gastroesophageal reflux in infants.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- A New, Noninvasive Accelerometric Method for Diagnosing Acid andNon-Acid Gastroesophageal Reflux in Premature Infants: Proof of Concept.Journal of medical devices · 2019Article
- Clinical Aspects of Thickeners for Pediatric Gastroesophageal Reflux and Oropharyngeal Dysphagia.Current gastroenterology reports · 2019Review
- Optimizing the Use of Medications and Other Therapies in Infant Gastroesophageal Reflux.Paediatric drugs · 2018Review
- The Characteristics of Esophageal Multichannel Intraluminal Impedance-PH Measurements in Infants Experiencing Brief Resolved Unexplained Events.Annals of gastroenterology and digestive disorders · 2018Article
- The Reliability of Electronic Health Record Data Used for Obstetrical Research.Applied clinical informatics · 2018Article
- Pharmacological management of gastroesophageal reflux disease in infants: current opinions.Current opinion in pharmacology · 2017Review
- Gastroesophageal Reflux Disease.Pediatric clinics of North America · 2017Review
- Correlation of Gastroesophageal reflux disease Assessment Symptom Questionnaire to impedance-pH measurements in children.SAGE open medicine · 2017Article
- Symptom Association: An Imperfect Pairing.Journal of pediatric gastroenterology and nutrition · 2016Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
objectivesMultichannel intraluminal impedance studies (MII-pH) have become the criterion standard for the diagnosis of gastroesophageal reflux (GER). Several clinical signs and symptoms that are attributed to GER during infancy may not be related to true reflux. Our objective was to correlate the observed reflux-like behaviors to reflux events on MII-pH studies.
methodsThis is a retrospective study on infants being evaluated for GER with MII. During the MII-pH study, the infants were observed for clinical behaviors. Symptom Index (SI), symptom sensitivity index (SSI), and symptom association probability were used to correlate symptoms with reflux events.
resultsOf 58 infants (40 preterm, 18 term) included in the study, only 6 infants (10%) had an abnormal MII-pH study. Irritability (32 infants), bradycardia (20), and desaturation (18) were the common signs and symptoms. A total of 2142 (755 acidic and 1386 nonacidic) reflux episodes and 953 clinical reflux behaviors were recorded. The incidence and pattern of GER was similar in preterm and term infants. There was no significant difference in GER episodes and acid exposure in preterm infants fed orally or via nasogastric tube. The symptom association probability was abnormal in only 6 (19%), 1 (5%), and 5 (28%) infants with irritability, bradycardia, and desaturation, respectively.
conclusionsThe prevalence of GER as detected by MII-pH was low (10%) in symptomatic preterm and term infants. The incidence and pattern of GER was similar in preterm and term infants. The majority of suspected clinical reflux behaviors did not correlate with reflux events.
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