Evidence map›Paper›PMID 26334098›Full record

ArticleOncotarget2015

Plasma fibrinogen levels are correlated with postoperative distant metastasis and prognosis in esophageal squamous cell carcinoma.

Danhong Zhang, Xia Zhou, Wuan Bao, Ying Chen, Lei Cheng, Guoqin Qiu, Liming Sheng, Yongling Ji, Xianghui Du

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Preoperative plasma fibrinogen is associated with poor prognosis in esophageal carcinoma: a meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018
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  17. A retrospective analysis of the application of the ElecsysJournal of clinical laboratory analysis · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Danhong ZhangDepartment of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Xia ZhouDepartment of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Wuan BaoDepartment of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Ying ChenDepartment of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Lei ChengDepartment of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Guoqin QiuDepartment of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Liming ShengDepartment of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Yongling JiDepartment of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Xianghui DuDepartment of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Zhejiang Cancer Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the correlation of preoperative plasma fibrinogen level with distant metastasis and prognosis in esophageal squamous cell carcinoma (ESCC). A total of 255 patients with ESCC who underwent surgery in Zhejiang cancer hospital (Hangzhou, China), between October 2006 and December 2009, were evaluated in this retrospective study. Population controls were selected from a pool of cancer-free subjects in the same region. Each patient and cancer-free people provided 3-mL pretreatment blood. Plasma fibrinogen level was measured by the Clauss method. The effects of hyperfibrinogenemia on locoregional relapse-free survival (LRFS), distant metastasis-free survival (DMFS), relapse-free survival (RFS), and overall survival (OS) were assessed using Kaplan-Meier analysis. Independent prognostic factors were identified in the multivariate Cox analysis. The proportion of hyperfibrinogenemia was higher in ESCC patients than those in controls (40.4% vs 13.6%). Subjects with hyperfibrinogenemia had a significantly higher risk of ESCC than those with normal plasma fibrinogen level (adjust OR = 4.61; 95% CI = 3.02-7.01, P < 0.001) after adjusted for age, sex and smoking status. The Kaplan-Meier curves showed that patients with hyperfibrinogenemia had worse DMFS, RFS and OS (P < 0.001). Tumor length, lymph node metastasis and plasma fibrinogen level were independent prognostic factors of ESCC (P < 0.05). Increased plasma fibrinogen level was significantly associated with elevated risk of ESCC. Preoperative plasma fibrinogen level was a predictor of distant metastasis and independently associated with prognosis of patients with ESCC.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Squamous CellChinaChi-Square DistributionDisease-Free SurvivalDisease ProgressionEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaEsophagectomyFemaleFibrinogenHumansKaplan-Meier EstimateBiomarkers, TumorFibrinogenesophageal squamous cell carcinomafibrinogenmetastasisprognosis

Identifiers

PMID26334098
PMCPMC4742009
OpenAlexW2260757937

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.