ArticleScientific reports2015
The novel ABC transporter ABCH1 is a potential target for RNAi-based insect pest control and resistance management.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Silencing of juvenile hormone-related genes through RNA interference leads to molt failure and high mortality in the spongy moth.Insect science · 2026Article
- Down-regulation of the PxJHE2 gene elevates juvenile hormone titers and compensates for fitness costs of Bt Cry1Ac resistance in Plutella xylostella (L.).Pest management science · 2026Article
- Interference of ATP-Binding Cassette Transporter by Functional Nano-Delivery System for High Efficiency Management of Insecticide-Resistant Nilaparvata lugens.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- RNAi targeting ABCB1-like efflux transporters improves miticide efficacy in resistant Varroa mites.Parasites & vectors · 2026Article
- Article
- Revisiting strategies to target ABC transporter-mediated drug resistance in CNS cancer.Cancer biology & medicine · 2025Review
- Genomic functional annotation and comparative analysis of ABC transporter protein family genes in nine types of Chironomidae insects.BMC genomics · 2025Article
- The role of GPI-anchored membrane-bound alkaline phosphatase in the mode of action of Bt Cry1A toxins in the diamondback moth.Fundamental research · 2025Article
- ABCH2 transporter mediates deltamethrin uptake and toxicity in the malaria vector Anopheles coluzzii.PLoS pathogens · 2023Article
- Analysis of the Effect ofToxins · 2023Article
- Silencing ofInsects · 2022Article
- Functional Diversity of the Lepidopteran ATP-Binding Cassette Transporters.Journal of molecular evolution · 2022Review
- Genome-Wide Identification, Characterisation and Phylogenetic Analysis of 52 Striped Catfish (Tropical life sciences research · 2022Article
- Knockout of ABC TransporterToxins · 2022Article
- RNA interference (RNAi) applications to the management of fall armyworm,Frontiers in molecular biosciences · 2022Review
- A Novel Reference for Bt-Resistance Mechanism inInsects · 2021Article
- Innate and adaptive resistance to RNAi: a major challenge and hurdle to the development of double stranded RNA-based pesticides.3 Biotech · 2021Review
- The regulation landscape of MAPK signaling cascade for thwarting Bacillus thuringiensis infection in an insect host.PLoS pathogens · 2021Article
- Comparative and functional genomics of the ABC transporter superfamily across arthropods.BMC genomics · 2021Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insect pests cause serious crop damage and develop high-level resistance to chemical insecticides and Bacillus thuringiensis (Bt) insecticidal Cry toxins. A new promising approach for controlling them and overcoming this resistance is RNA interference (RNAi). The RNAi-based insect control strategy depends on the selection of suitable target genes. In this study, we cloned and characterized a novel ABC transporter gene PxABCH1 in diamondback moth, Plutella xylostella (L.). Phylogenetic analysis showed that PxABCH1 is closely related to ABCA and ABCG subfamily members. Spatial-temporal expression detection revealed that PxABCH1 was expressed in all tissues and developmental stages, and highest expressed in head and male adult. Midgut sequence variation and expression analyses of PxABCH1 in all the susceptible and Bt-resistant P. xylostella strains and the functional analysis by sublethal RNAi demonstrated that Cry1Ac resistance was independent of this gene. Silencing of PxABCH1 by a relatively high dose of dsRNA dramatically reduced its expression and resulted in larval and pupal lethal phenotypes in both susceptible and Cry1Ac-resistant P. xylostella strains. To our knowledge, this study provides the first insight into ABCH1 in lepidopterans and reveals it as an excellent target for RNAi-based insect pest control and resistance management.
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