Evidence map›Paper›PMID 26333785›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2015

Satellite cell activity, without expansion, after nonhypertrophic stimuli.

Sophie Joanisse, Bryon R McKay, Joshua P Nederveen, Trisha D Scribbans, Brendon J Gurd, Jenna B Gillen, Martin J Gibala, Mark Tarnopolsky, Gianni Parise

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Skeletal Muscle Satellite Cells in Sickle Cell Disease Patients and Their Responses to a Moderate-intensity Endurance Exercise Training Program.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022
    Article
  12. Article
  13. Fusion and beyond: Satellite cell contributions to loading-induced skeletal muscle adaptation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sophie JoanisseDepartments of Kinesiology, McMaster University, Hamilton, Ontario, Canada;
Bryon R McKayDepartments of Kinesiology, McMaster University, Hamilton, Ontario, Canada;
Joshua P NederveenDepartments of Kinesiology, McMaster University, Hamilton, Ontario, Canada;
Trisha D ScribbansSchool of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada;
Brendon J GurdSchool of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada;
Jenna B GillenDepartments of Kinesiology, McMaster University, Hamilton, Ontario, Canada;
Martin J GibalaDepartments of Kinesiology, McMaster University, Hamilton, Ontario, Canada;
Mark TarnopolskyDepartment of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada; and.
Gianni PariseDepartments of Kinesiology, McMaster University, Hamilton, Ontario, Canada; Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada pariseg@mcmaster.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of the present studies was to determine the effect of various nonhypertrophic exercise stimuli on satellite cell (SC) pool activity in human skeletal muscle. Previously untrained men and women (men: 29 ± 9 yr and women: 29 ± 2 yr, n = 7 each) completed 6 wk of very low-volume high-intensity sprint interval training. In a separate study, recreationally active men (n = 16) and women (n = 3) completed 6 wk of either traditional moderate-intensity continuous exercise (n = 9, 21 ± 4 yr) or low-volume sprint interval training (n = 10, 21 ± 2 yr). Muscle biopsies were obtained from the vastus lateralis before and after training. The fiber type-specific SC response to training was determined, as was the activity of the SC pool using immunofluorescent microscopy of muscle cross sections. Training did not induce hypertrophy, as assessed by muscle cross-sectional area, nor did the SC pool expand in any group. However, there was an increase in the number of active SCs after each intervention. Specifically, the number of activated (Pax7(+)/MyoD(+), P ≤ 0.05) and differentiating (Pax7(-)/MyoD(+), P ≤ 0.05) SCs increased after each training intervention. Here, we report evidence of activated and cycling SCs that may or may not contribute to exercise-induced adaptations while the SC pool remains constant after three nonhypertrophic exercise training protocols.

Indexed as

Adaptation, PhysiologicalAdultCell DifferentiationCell ProliferationExerciseFemaleHumansHypertrophyMaleMuscle, SkeletalPhysical Conditioning, HumanPhysical ExertionSatellite Cells, Skeletal Muscleendurance trainingmuscle stem cellsMyoDPax7sprint interval training

Identifiers

PMID26333785
PMCPMC4666950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.