ArticleBiology letters2015
No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat.
Article in Biology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Handling Stress and Sample Storage Are Associated with Weaker Complement-Mediated Bactericidal Ability in Birds but Not Bats.Physiological and biochemical zoology : PBZPooled it
- Diverse hosts, diverse immune systems: Evolutionary variation in bat immunology.Annals of the New York Academy of Sciences · 2025Review
- Integrating natural commensals and pathogens into preclinical mouse models.Nature reviews. Immunology · 2025Review
- Article
- Experimental infection of Artibeus lituratus bats and no detection of Zika virus in neotropical bats from French Guiana, Peru, and Costa Rica suggests a limited role of bats in Zika transmission.PLoS neglected tropical diseases · 2023Article
- Bat behavioral immune responses in social contexts: current knowledge and future directions.Frontiers in immunology · 2023Review
- Lipopolysaccharide detection by the innate immune system may be an uncommon defence strategy used in nature.Open biology · 2022Review
- Review
- Do gastrointestinal microbiomes play a role in bats' unique viral hosting capacity?Trends in microbiology · 2022Review
- Sick bats stay home alone: fruit bats practice social distancing when faced with an immunological challenge.Annals of the New York Academy of Sciences · 2021Article
- Host specificity of the gut microbiome.Nature reviews. Microbiology · 2021Review
- Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection.Cell reports · 2020Article
- The immune response of bats differs between pre-migration and migration seasons.Scientific reports · 2020Article
- Immune-challenged vampire bats produce fewer contact calls.Biology letters · 2020Article
- Going to Bat(s) for Studies of Disease Tolerance.Frontiers in immunology · 2018Review
- Article
- Heart rate reveals torpor at high body temperatures in lowland tropical free-tailed bats.Royal Society open science · 2017Article
- Article
- Habitat disturbance results in chronic stress and impaired health status in forest-dwelling paleotropical bats.Conservation physiology · 2017Article
- Simulated bacterial infection disrupts the circadian fluctuation of immune cells in wrinkle-lipped bats (PeerJ · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bat immune systems may allow them to respond to zoonotic agents more efficiently than other mammals. As the first line of defence, the taxonomically conserved acute phase immune reaction of leucocytosis and fever is crucial for coping with infections, but it is unknown if this response is a key constituent to bat immunological success. We investigated the acute phase reaction to a standard lipopolysaccharide (LPS) challenge in Pallas's mastiff bats (Molossus molossus). Challenged bats lost mass, but in contrast to other mammals showed no leucocytosis or fever. There also was no influence on body temperature reduction during torpor. When compared to recent genome-wide assays for constituent immune genes, this lack of a conserved fever response to LPS contributes to a clearer understanding of the innate immune system in bat species and of the coevolution of bats with a wide diversity of pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.