Evidence map›Paper›PMID 26333571›Full record

ArticlePathogens and disease2015

Angiogenic, lymphangiogenic and adipogenic effects of HIV-1 matrix protein p17.

Daniele Basta, Olga Latinovic, Mark K Lafferty, Lingling Sun, Joseph Bryant, Wuyuan Lu, Francesca Caccuri, Arnaldo Caruso, Robert Gallo, Alfredo Garzino-Demo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens and disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Role of HIV-1 matrix protein p17 variants in lymphoma pathogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Trial
  2. HIV reservoirs in lymphomagenesis: hidden driver in the era of viral suppression?Microbiology and molecular biology reviews : MMBR · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Expression of HIV-1 matrix protein p17 and association with B-cell lymphoma in HIV-1 transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Daniele BastaInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA Microbiology Section, Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy.
Olga LatinovicInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA Department of Microbiology and Immunology, Baltimore, MD 21201, USA.
Mark K LaffertyInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Lingling SunInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Joseph BryantInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Wuyuan LuInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA Department of Biochemistry and Molecular Biology, Baltimore, MD 21201, USA.
Francesca CaccuriInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Arnaldo CarusoMicrobiology Section, Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy.
Robert GalloInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Alfredo Garzino-DemoInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA Department of Microbiology and Immunology, Baltimore, MD 21201, USA Department of Molecular Medicine, University of Padova, 35123, Italy agarzinodemo@ihv.umaryland.edu alfredo.garzinodemo@unipd.it.
University of Maryland, Baltimore · USUniversity of Brescia · ITUniversity of Padua · IT

Funding

Training Grant in Cancer BiologyT32CA154274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI Toni M Antalis, CURT I CIVIN · 2011 to 2026
$6.8M
Inhibition of Anthrax Lethal Factor by alpha-defensinsR01AI072732 · NIAID · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI LU, WUYUAN · 2007 to 2011
$2.4M
A Novel Anti-HIV Activity of CCR6 via APOBEC3G: Relevance to CNS InfectionR01NS066842 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI GARZINO-DEMO, ALFREDO · 2009 to 2013
$1.7M
NCI NIH HHS 1T32 CA154274NCI NIH HHS T32 CA154274NIAID NIH HHS AI-072732NINDS NIH HHS NS-066842
6 · The paper itself

Abstract

Lymphangiogenesis and concurrent angiogenesis are essential in supporting proliferation and survival of AIDS-related lymphomas, which are often metastatic. In vitro studies suggest a candidate angiogienic and lymphangiogenic factor encoded by HIV: the matrix protein p17. p17 accumulates in lymph nodes of patients even when they are undergoing highly active antiretroviral therapy. p17 has been found to affect immune cells, and recent data showed that a variant p17, called S75X, induces cell growth by triggering MAPK/ERK and PI3K/AKT pathways. We tested the in vivo angiogenic activity of p17 by injecting it in Matrigel plugs in nude mice. Plugs were retrieved 7 days after injection, and assessed macroscopically, and by light and confocal microscopy. Our data revealed that both reference and S75X variant p17 promote angiogenesis and lymphangiogenesis in vivo. Our results suggest that the induction of angiogenesis and lymphangiogenesis by HIV-1 p17 may generate a favorable microenvironment that could trigger tumor growth and maintenance. Moreover, the presence of adipocytes infiltration observed at the histological level suggests a possible interplay between angiogenesis, lymphangiogenesis and adipogenesis. These findings offer new opportunities for the development of treatment strategies to combat HIV-related cancers.

Indexed as

AdipogenesisAnimalsgag Gene Products, Human Immunodeficiency VirusHIV-1HIV AntigensLymphangiogenesisMice, NudeMicroscopyNeovascularization, Pathologicgag Gene Products, Human Immunodeficiency VirusHIV Antigensp17 protein, Human Immunodeficiency Virus Type 1adipogenesisangiogienesisHIV-1lymphangiogenesislymphomagenesismatrix protein

Identifiers

PMID26333571
PMCPMC4626619
OpenAlexW2294567834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.