ArticlePloS one2015
Representativeness of the LifeLines Cohort Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers, 3 of them syntheses that pooled it.
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Who cites it
183 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Sugar-sweetened beverages, low/no-calorie beverages, fruit juice and non-alcoholic fatty liver disease defined by fatty liver index: the SWEET project.Nutrition & diabetes · 2023Pooled it
- Temporal exposure and consistency of endocrine disrupting chemicals in a longitudinal study of individuals with impaired fasting glucose.Environmental research · 2021Pooled it
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- Cohort Profile: The European Occupational Exposome Mega Cohort Consortium (OMega-X).International journal of epidemiology · 2026Article
- Association of atopic multimorbidity with childhood pet exposure and caesarean section delivery: a retrospective study from the Lifelines Cohort Study.Skin health and disease · 2026Article
- Contribution of genetic and environmental factors to obesity indices and their overlap.Diabetes, obesity & metabolism · 2026Article
- Simulating COVID-19 lockdowns' impact on depressive symptoms in the northern Netherlands.BMC public health · 2026Article
- Genetic underpinnings of chills from art and music.PLoS genetics · 2026Article
- Maternal Health Matters: Exploring the Links Between Parental Health and Illness Factors and Adolescent Functional Somatic Symptoms.JAACAP open · 2026Article
- The Association of Hair Dye Use With Sociodemographic and Lifestyle Factors in the Dutch General Population: A Cross-Sectional Questionnaire-Based Study.Contact dermatitis · 2026Article
- Cardiovascular-kidney-metabolic syndrome: candidate subtypes and genetic risk factors.BMC medical genomics · 2026Article
- Disentangling comorbidity: symptom dimensions of internalizing and functional disorders in a large general population sample.BMC psychiatry · 2026Article
- Challenges of using the Occupational Asthma-specific job exposure matrix to assess occupational exposure and hand eczema.Frontiers in allergy · 2026Article
- Article
- Impact of Physical Activity on Metastatic Cancer at Diagnosis and Mortality: Results from the Lifelines Cohort Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Productivity changes during the COVID-19 pandemic and its associated risk factors.Scandinavian journal of work, environment & health · 2025Article
- Clonal haematopoiesis associates with distinct cytometric changes of red blood cells and platelets.British journal of haematology · 2025Article
- Associations of Demographic, Lifestyle, and Clinical Factors With the Presence of Dupuytren Disease: Results from the Lifelines Cohort Study.Journal of hand surgery global online · 2025Article
123 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLifeLines is a large prospective population-based three generation cohort study in the north of the Netherlands. Different recruitment strategies were adopted: recruitment of an index population via general practitioners, subsequent inclusion of their family members, and online self-registration. Our aim was to investigate the representativeness of the adult study population at baseline and to evaluate differences in the study population according to recruitment strategy.
methodsDemographic characteristics of the LifeLines study population, recruited between 2006-2013, were compared with the total adult population in the north of the Netherlands as registered in the Dutch population register. Socioeconomic characteristics, lifestyle, chronic diseases, and general health were further compared with participants of the Permanent Survey of Living Conditions within the region (2005-2011, N = 6,093). Differences according to recruitment strategy were assessed.
resultsCompared with the population of the north of the Netherlands, LifeLines participants were more often female, middle aged, married, living in a semi-urban place and Dutch native. Adjusted for differences in demographic composition, in LifeLines a smaller proportion had a low educational attainment (5% versus 14%) or had ever smoked (54% versus 66%). Differences in the prevalence of various chronic diseases and low general health scores were mostly smaller than 3%. The age profiles of the three recruitment groups differed due to age related inclusion criteria of the recruitment groups. Other differences according to recruitment strategy were small.
conclusionsOur results suggest that, adjusted for differences in demographic composition, the LifeLines adult study population is broadly representative for the adult population of the north of the Netherlands. The recruitment strategy had a minor effect on the level of representativeness. These findings indicate that the risk of selection bias is low and that risk estimates in LifeLines can be generalized to the general population.
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