Evidence map›Paper›PMID 26332964›Full record

ReviewDiabetes, obesity & metabolism2015

Coupling circadian rhythms of metabolism and chromatin remodelling.

S Masri, R Orozco-Solis, L Aguilar-Arnal, M Cervantes, P Sassone-Corsi

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetes, obesity & metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Circadian regulation of stereotypic chromatin conformations at enhancers.bioRxiv : the preprint server for biology · 2024
    Article
  3. Review
  4. Review
  5. Animals : an open access journal from MDPI · 2021
    Article
  6. Review
  7. Circadian Clocks, Sleep, and Metabolism.Advances in experimental medicine and biology · 2021
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

S MasriCenter for Epigenetics and Metabolism, Unit 904 of INSERM, Department of Biological Chemistry, University of California, Irvine, CA, USA.
R Orozco-SolisCenter for Epigenetics and Metabolism, Unit 904 of INSERM, Department of Biological Chemistry, University of California, Irvine, CA, USA.
L Aguilar-ArnalCenter for Epigenetics and Metabolism, Unit 904 of INSERM, Department of Biological Chemistry, University of California, Irvine, CA, USA.
M CervantesCenter for Epigenetics and Metabolism, Unit 904 of INSERM, Department of Biological Chemistry, University of California, Irvine, CA, USA.
P Sassone-CorsiCenter for Epigenetics and Metabolism, Unit 904 of INSERM, Department of Biological Chemistry, University of California, Irvine, CA, USA.
University of California, Irvine · US

Funding

The Circadian Metabolome and its Interplay with Nutritional ChallengesR21DA036408 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI SASSONE-CORSI, PAOLO · 2013 to 2014
$424k
SIRT1 and MLL1 Interplay in circadian clock functionR21AG041504 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI SASSONE-CORSI, PAOLO · 2011 to 2012
$421k
NIA NIH HHS R21 AG041504NIDA NIH HHS DA036408
6 · The paper itself

Abstract

The circadian clock controls a large variety of neuronal, endocrine, behavioural and physiological responses in mammals. This control is exerted in large part at the transcriptional level on genes expressed in a cyclic manner. A highly specialized transcriptional machinery based on clock regulatory factors organized in feedback autoregulatory loops governs a significant portion of the genome. These oscillations in gene expression are paralleled by critical events of chromatin remodelling that appear to provide plasticity to circadian regulation. Specifically, the nicotinamide adenine dinucleotide (NAD)(+) -dependent deacetylases SIRT1 and SIRT6 have been linked to circadian control of gene expression. This, and additional accumulating evidence, shows that the circadian epigenome appears to share intimate links with cellular metabolic processes and has remarkable plasticity showing reprogramming in response to nutritional challenges. In addition to SIRT1 and SIRT6, a number of chromatin remodellers have been implicated in clock control, including the histone H3K4 tri-methyltransferase MLL1. Deciphering the molecular mechanisms that link metabolism, epigenetic control and circadian responses will provide valuable insights towards innovative strategies of therapeutic intervention.

Indexed as

Chromatin Assembly and DisassemblyTranscription, GeneticAnimalsCellsCircadian RhythmCLOCK ProteinsEpigenomicsGene ExpressionHumansMammalsNADNutritional Physiological PhenomenaSirtuin 1SirtuinsCLOCK ProteinsNADSIRT1 protein, humanSIRT6 protein, humanSirtuin 1Sirtuinschromatin remodellingepigeneticsNAD+nutritionsirtuins

Identifiers

PMID26332964
PMCPMC4732882
OpenAlexW1850076157

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.