Evidence map›Paper›PMID 26332868›Full record

ArticleNeurourology and urodynamics2016

Impact of childhood and recent traumatic events on the clinical presentation of overactive bladder.

H Henry Lai, Clinton D Morgan, Joel Vetter, Gerald L Andriole

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Neurourology and urodynamics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03480477 (Adverse Childhood Experiences in Urogynecologic Patients), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03480477 terminatednot on this mapstarted 2018, after this paper: background citation

Adverse Childhood Experiences in Urogynecologic Patients

TypeobservationalSponsorUniversity of New MexicoRan2018 to 2019Enrolled356ConditionsPelvic Floor Disorders, Interstitial Cystitis, Urinary IncontinenceArmsACE questionnaire
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
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  9. Acceptability and Perceived Utility of Virtual Reality Among People Who Are Incarcerated Who Use Drugs.Journal of correctional health care : the official journal of the National Commission on Correctional Health Care · 2024
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  20. Is overactive bladder independently associated with anxiety?International urogynecology journal · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

H Henry LaiDivision of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri. laih@wustl.edu.
Clinton D MorganDivision of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri.
Joel VetterDivision of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri.
Gerald L AndrioleDivision of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri.
Washington University in St. Louis · US

Funding

BIOLOGY AND PATHOPHYSIOLOGY OF UROTHELIUM IN BLADDER DISEASE P20DK097798 · NIDDK · WASHINGTON UNIVERSITY · PI ANDRIOLE, GERALD LOUIS · 2012 to 2013
$796k
THE ROLE OF METABOTROPIC GLUTAMATE RECEPTOR 5 (MGLUR5) IN BLADDER PAINK08DK094964 · NIDDK · WASHINGTON UNIVERSITY · PI LAI, HING HUNG HENRY · 2013 to 2017
$700k
Howard Hughes Medical InstituteNIDDK NIH HHS K08 DK094964NIDDK NIH HHS P20 DK097798
6 · The paper itself

Abstract

aims(1) To describe the Prevalence of childhood and recent trauma in patients with overactive bladder (OAB), and (2) assess the impact of traumatic events on the clinical presentation and the severity of OAB symptoms, quality of life, and psychosocial health.

methodsPatients diagnosed with OAB (n = 51) and age-matched healthy controls (n = 30) were administered the Childhood Traumatic Events Scale and Recent Traumatic Events Scale, assessing exposure and perceived impact of common traumatic events. Among OAB patients, validated instruments were administered to correlate traumatic exposure to evaluate adult urinary symptoms (ICIQ-UI, ICIQ-OAB, OAB-q, UDI-6, IIQ-7, USS), mood dysregulation (HADS), sleep and fatigue (PROMIS), and Psychological stress (PSS).

resultsChildhood sexual trauma was more prevalent in patients with OAB compared to controls (29.4% vs. 6.7%, P = 0.041). OAB patients also rated their childhood sexual exposure as more traumatic compared to controls (mean ratings of 1.7 vs. 0.4, P = 0.050). There was no difference in childhood deaths (P = 0.24), parental upheaval (P = 0.87), violence (P = 0.099), illness/injury (P = 0.683), or any recent traumatic events between OAB and control subjects. Childhood trauma predicted worse bladder pain (P = 0.005), worse non-urologic pain (P = 0.017), poorer mood (P = 0.001), higher anxiety (P = 0.029), higher physical symptom burden (P < 0.001), and higher psychological stress (P < 0.039). However, childhood trauma did not correlate with the severity of OAB symptoms (urgency, frequency, incontinence).

conclusionsThirty percent of OAB patients reported childhood sexual trauma. These patients report more pain symptoms, poorer mood, and greater somatic burden. These data highlight the potentiating role of psychosocial stressors from childhood in the adult suffering from OAB. Neurourol. Urodynam. 35:1017-1023, 2016. © 2015 Wiley periodicals, Inc.

Indexed as

Child Abuse, SexualAdultAgedAge FactorsChildCost of IllnessFemaleHumansLife Change EventsMaleMental HealthMiddle AgedNeuropsychological TestsPainPrevalenceQuality of Lifechildhood traumaoveractive bladder

Identifiers

PMID26332868
PMCPMC4942378
OpenAlexW1782592324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.