Evidence map›Paper›PMID 26332834›Full record

SynthesisPloS one2015

Obesity and Risk for Brain/CNS Tumors, Gliomas and Meningiomas: A Meta-Analysis.

Theodoros N Sergentanis, Georgios Tsivgoulis, Christina Perlepe, Ioannis Ntanasis-Stathopoulos, Ioannis-Georgios Tzanninis, Ioannis N Sergentanis, Theodora Psaltopoulou

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.

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  5. Olfactory Groove Meningiomas and the Association with Postoperative Weight Loss.Journal of neurological surgery. Part B, Skull base · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Theodoros N SergentanisDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National University of Athens, Athens, Greece.
Georgios TsivgoulisSecond Department of Neurology, "Attikon" University Hospital, Medical School, National University of Athens, Athens, Greece.
Christina PerlepeDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National University of Athens, Athens, Greece.
Ioannis Ntanasis-StathopoulosDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National University of Athens, Athens, Greece.
Ioannis-Georgios TzanninisDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National University of Athens, Athens, Greece.
Ioannis N SergentanisHôpital de Psychiatrie, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
Theodora PsaltopoulouDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National University of Athens, Athens, Greece.
National and Kapodistrian University of Athens · GRHôpital Beau-Séjour · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis meta-analysis aims to examine the association between being overweight/obese and risk of meningiomas and gliomas as well as overall brain/central nervous system (CNS) tumors. STUDY

designPotentially eligible publications were sought in PubMed up to June 30, 2014. Random-effects meta-analysis and dose-response meta-regression analysis was conducted. Cochran Q statistic, I-squared and tau-squared were used for the assessment of between-study heterogeneity. The analysis was performed using Stata/SE version 13 statistical software.

resultsA total of 22 studies were eligible, namely 14 cohort studies (10,219 incident brain/CNS tumor cases, 1,319 meningioma and 2,418 glioma cases in a total cohort size of 10,143,803 subjects) and eight case-control studies (1,009 brain/CNS cases, 1,977 meningioma cases, 1,265 glioma cases and 8,316 controls). In females, overweight status/obesity was associated with increased risk for overall brain/CNS tumors (pooled RR = 1.12, 95%CI: 1.03-1.21, 10 study arms), meningiomas (pooled RR = 1.27, 95%CI: 1.13-1.43, 16 study arms) and gliomas (pooled RR = 1.17, 95%CI: 1.03-1.32, six arms). Obese (BMI>30 kg/m2) females seemed particularly aggravated in terms of brain/CNS tumor (pooled RR = 1.19, 95%CI: 1.05-1.36, six study arms) and meningioma risk (pooled RR = 1.48, 95%CI: 1.28-1.71, seven arms). In males, overweight/obesity status correlated with increased meningioma risk (pooled RR = 1.58, 95%CI: 1.22-2.04, nine study arms), whereas the respective association with overall brain/CNS tumor or glioma risk was not statistically significant. Dose-response meta-regression analysis further validated the findings.

conclusionOur findings highlight obesity as a risk factor for overall brain/CNS tumors, meningiomas and gliomas among females, as well as for meningiomas among males.

Indexed as

Body Mass IndexBrain NeoplasmsCentral Nervous System NeoplasmsFemaleGliomaHumansMaleMeningeal NeoplasmsMeningiomaObesityOverweightRisk FactorsSex Factors

Identifiers

PMID26332834
PMCPMC4558052
OpenAlexW1853229101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.