ReviewClinical and experimental immunology2016
The ageing human B cell repertoire: a failure of selection?
Review in Clinical and experimental immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 68 citations in OpenAlex.
- Article
- Small Nucleolar RNAs: Biological Functions and Diseases.MedComm · 2025Review
- Clinical application of mesenchymal stem cells in immunosenescence: a qualitative review of their potential and challenges.Stem cell research & therapy · 2025Review
- Immunoglobulin: unraveling its complex web in aging.Frontiers in immunology · 2025Review
- Dietary restriction mitigates the age-associated decline in mouse B cell receptor repertoire diversity.Cell reports · 2023Article
- Article
- The memory B cell response to influenza vaccination is impaired in older persons.Cell reports · 2022Article
- A gut-centric view of aging: Do intestinal epithelial cells contribute to age-associated microbiota changes, inflammaging, and immunosenescence?Aging cell · 2022Review
- How Can We Improve the Vaccination Response in Older People? Part II: Targeting Immunosenescence of Adaptive Immunity Cells.International journal of molecular sciences · 2022Review
- High-risk subtypes of chronic lymphocytic leukemia are detectable as early as 16 years prior to diagnosis.Blood · 2022Article
- Mechanisms underpinning poor antibody responses to vaccines in ageing.Immunology letters · 2022Review
- Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis.Frontiers in immunology · 2022Review
- Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus.Frontiers in immunology · 2022Article
- Tapping the immunological imprints to design chimeric SARS-CoV-2 vaccine for elderly population.International reviews of immunology · 2022Review
- Analysis of the heterogeneity of the BCR H-CDR3 repertoire in the bone marrow and spleen of 3-, 12-, and 20-month old mice.Immunity & ageing : I & A · 2021Article
- B-cell capacity for differentiation changes with age.Aging cell · 2021Article
- The Dynamics of B Cell Aging in Health and Disease.Frontiers in immunology · 2021Review
- Sex-Biased Aging Effects on Ig Somatic Hypermutation Targeting.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Unique Transcriptome Changes in Peripheral B Cells Revealed by Comparing Age Groups From Naive or Vaccinated Mice, Including snoRNA and Cdkn2a.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
B cells undergo a number of different developmental stages, from initial formation of their B cell receptor (BCR) genes to differentiation into antibody-secreting plasma cells. Because the BCR is vital in these differentiation steps, autoreactive and exogenous antigen binding to the BCR exert critical selection pressures to shape the B cell repertoire. Older people are more prone to infectious disease, less able to respond well to vaccination and more likely to have autoreactive antibodies. Here we review evidence of changes in B cell repertoires in older people, which may be a reflection of age-related changes in B cell selection processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.