ArticleThe Journal of physiology2016
Gestational nanomaterial exposures: microvascular implications during pregnancy, fetal development and adulthood.
Article in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- The association of prenatal ambient air pollution with placental epigenetic gestational age at birth.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- The Effects of BSA-Stabilized Selenium Nanoparticles and Sodium Selenite Supplementation on the Structure, Oxidative Stress Parameters and Selenium Redox Biology in Rat Placenta.International journal of molecular sciences · 2022Article
- Nanotechnologies in Obstetrics and Cancer during Pregnancy: A Narrative Review.Journal of personalized medicine · 2022Review
- Autism-like symptoms by exposure to air pollution and valproic acid-induced in male rats.Environmental science and pollution research international · 2022Article
- What to Expect When Expecting in Lab: A Review of Unique Risks and Resources for Pregnant Researchers in the Chemical Laboratory.Chemical research in toxicology · 2022Review
- Targeted drug delivery for maternal and perinatal health: Challenges and opportunities.Advanced drug delivery reviews · 2021Review
- Development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation.Scientific reports · 2021Article
- Design of nanomaterials for applications in maternal/fetal medicine.Journal of materials chemistry. B · 2020Review
- Recent insights on indirect mechanisms in developmental toxicity of nanomaterials.Particle and fibre toxicology · 2020Review
- Mild steel and stainless steel welding fumes elicit pro-inflammatory and pro-oxidant effects in first trimester trophoblast cells.American journal of reproductive immunology (New York, N.Y. : 1989) · 2020Article
- Effects of PMParticle and fibre toxicology · 2020Article
- Developmental onset of cardiovascular disease-Could the proof be in the placenta?Microcirculation (New York, N.Y. : 1994) · 2019Review
- Identification and quantification of gold engineered nanomaterials and impaired fluid transfer across the rat placenta via ex vivo perfusion.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2019Article
- Estrous cycle-dependent modulation of in vivo microvascular dysfunction after nanomaterial inhalation.Reproductive toxicology (Elmsford, N.Y.) · 2018Article
- Engineered nanomaterial applications in perinatal therapeutics.Pharmacological research · 2018Review
- Maternal engineered nanomaterial inhalation during gestation alters the fetal transcriptome.Particle and fibre toxicology · 2018Article
- Transcriptome-wide based identification of miRs in congenital anomalies of the kidney and urinary tract (CAKUT) in children: the significant upregulation of tissue miR-144 expression.Journal of translational medicine · 2016Article
- Cardiovascular and skeletal muscle ageing: consequences for longevity.The Journal of physiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Air pollution particulate matter and engineered nanomaterials are encompassed in the broad definition of xenobiotic particles. While the effects of perinatal air pollution exposure have been investigated, elucidation of outcomes associated with nanomaterial exposure, the focus of this review, is still in its infancy. As the potential uses of nanomaterials, and therefore exposures, increase exponentially so does the need for thorough evaluation. Up to this point, the majority of research in the field of cardiovascular nanotoxicology has focused on the coronary and vascular reactions to pulmonary exposures in young adult, healthy, male models; however, as intentional and unintentional contacts persist, the non-pulmonary risks to under-represented populations become a critical concern. Development of the maternal-fetal circulation during successful mammalian gestation is one of the most unusual complex, dynamic, and acutely demanding physiological systems. Fetal development in a hostile gestational environment can lead to systemic alterations, which may encourage adult disease. Therefore, the purpose of this review is to highlight the few knowns associated with gestational engineered nanomaterial exposure segmented by physiological periods of development or systemic targets: preconception and maternal, gestational, fetal and progeny (Abstract figure). Overall, the limited studies currently available provide compelling evidence of maternal, fetal and offspring dysfunctions after engineered nanomaterial exposure. Understanding the mechanisms associated with these multigenerational effects may allow pregnant women to safely reap the benefits of nanotechnology-enabled products and assist in the implementation of exposure controls to protect the mother and fetus allowing for development of safety by design for engineered nanomaterials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.