ArticleRevista Brasileira de terapia intensiva
Main characteristics observed in patients with hematologic diseases admitted to an intensive care unit of a Brazilian university hospital.
Article in Revista Brasileira de terapia intensiva. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Management strategy for hematological malignancy patients with acute respiratory failure.European journal of medical research · 2021Review
- Epidemiology, Clinical Characteristics, and Prognostic Factors in Critically Ill Patients with Hematolymphoid Malignancy.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Factors associated with non-invasive mechanical ventilation failure in patients with hematological neoplasia and their association with outcomes.Journal of intensive care · 2020Article
- Neutrophil-lymphocyte ratio in the early diagnosis of sepsis in an intensive care unit: a case-control study.Revista Brasileira de terapia intensiva · 2019Article
- Characteristics and Outcomes of Patients with Hematological Malignancies Admitted for Intensive Care - a Single Centre ExperienceAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Patients with hematological malignancies admitted to intensive care units: new challenges for the intensivist.Revista Brasileira de terapia intensivaArticle
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Abstract
objectiveTo evaluate the clinical characteristics of patients with hematological disease admitted to the intensive care unit and the use of noninvasive mechanical ventilation in a subgroup with respiratory dysfunction.
methodsA retrospective observational study from September 2011 to January 2014.
resultsOverall, 157 patients were included. The mean age was 45.13 (± 17.2) years and 46.5% of the patients were female. Sixty-seven (48.4%) patients had sepsis, and 90 (57.3%) patients required vasoactive vasopressors. The main cause for admission to the intensive care unit was acute respiratory failure (94.3%). Among the 157 studied patients, 47 (29.9%) were intubated within the first 24 hours, and 38 (24.2%) underwent noninvasive mechanical ventilation. Among the 38 patients who initially received noninvasive mechanical ventilation, 26 (68.4%) were subsequently intubated, and 12 (31.6%) responded to this mode of ventilation. Patients who failed to respond to noninvasive mechanical ventilation had higher intensive care unit mortality (66.7% versus 16.7%; p = 0.004) and a longer stay in the intensive care unit (9.6 days versus 4.6 days, p = 0.02) compared with the successful cases. Baseline severity scores (SOFA and SAPS 3) and the total leukocyte count were not significantly different between these two subgroups. In a multivariate logistic regression model including the 157 patients, intubation at any time during the stay in the intensive care unit and SAPS 3 were independently associated with intensive care unit mortality, while using noninvasive mechanical ventilation was not.
conclusionIn this retrospective study with severely ill hematologic patients, those who underwent noninvasive mechanical ventilation at admission and failed to respond to it presented elevated intensive care unit mortality. However, only intubation during the intensive care unit stay was independently associated with a poor outcome. Further studies are needed to define predictors of noninvasive mechanical ventilation failure.
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