ArticleAnalytical chemistry2015
Acoustofluidic Fluorescence Activated Cell Sorter.
Article in Analytical chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Microfluidic technologies for enhancing the potency, predictability and affordability of adoptive cell therapies.Nature biomedical engineering · 2025Review
- Integration of acoustic, optical, and electrical methods in picoliter droplet microfluidics for rare particles enrichment.Communications engineering · 2025Article
- Deep Learning-Assisted Label-Free Parallel Cell Sorting with Digital Microfluidics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Effective Boundary Correction for Deterministic Lateral Displacement Microchannels to Improve Cell Separation: A Numerical and Experimental Study.Biosensors · 2024Article
- Acoustofluidic Actuation of Living Cells.Micromachines · 2024Review
- Advances in single-cell metabolomics to unravel cellular heterogeneity in plant biology.Plant physiology · 2023Review
- Continuous Flow Separation of Live and Dead Cells Using Gravity Sedimentation.Micromachines · 2023Article
- Image-based cell sorting using focused travelling surface acoustic waves.Lab on a chip · 2023Article
- Efficient recovery of potent tumour-infiltrating lymphocytes through quantitative immunomagnetic cell sorting.Nature biomedical engineering · 2022Article
- Label-free imaging flow cytometry for analysis and sorting of enzymatically dissociated tissues.Scientific reports · 2022Article
- Potential of the acoustic micromanipulation technologies for biomedical research.Biomicrofluidics · 2021Article
- Mattertronics for programmable manipulation and multiplex storage of pseudo-diamagnetic holes and label-free cells.Nature communications · 2021Article
- Acoustic Microfluidic Separation Techniques and Bioapplications: A Review.Micromachines · 2020Review
- Intelligent image-based deformation-assisted cell sorting with molecular specificity.Nature methods · 2020Article
- Morpho-Rheological Fingerprinting of Rod Photoreceptors Using Real-Time Deformability Cytometry.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2019Article
- Applications of Acoustofluidics in Bioanalytical Chemistry.Analytical chemistry · 2019Article
- Acoustofluidic separation of cells and particles.Microsystems & nanoengineering · 2019Article
- Microfluidic Based Optical Microscopes on Chip.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2018Review
- Microfluidic approaches for cell-based molecular diagnosis.Biomicrofluidics · 2018Article
- Label-free sorting of soft microparticles using a bioinspired synthetic cilia array.Biomicrofluidics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Selective isolation of cell subpopulations with defined biological characteristics is crucial for many biological studies and clinical applications. In this work, we present the development of an acoustofluidic fluorescence activated cell sorting (FACS) device that simultaneously performs on-demand, high-throughput, high-resolution cell detection and sorting, integrated onto a single chip. Our acoustofluidic FACS device uses the "microfluidic drifting" technique to precisely focus cells/particles three dimensionally and achieves a flow of single-file particles/cells as they pass through a laser interrogation region. We then utilize short bursts (150 μs) of standing surface acoustic waves (SSAW) triggered by an electronic feedback system to sort fluorescently labeled particles/cells with desired biological properties. We have demonstrated continuous isolation of fluorescently labeled HeLa cells from unlabeled cells at a throughput of ∼1200 events/s with a purity reaching 92.3 ± 3.39%. Furthermore, 99.18% postsort cell viability indicates that our acoustofluidic sorting technique maintains a high integrity of cells. Therefore, our integrated acoustofluidic FACS device is demonstrated to achieve two-way cell sorting with high purity, biocompatibility, and biosafety. We believe that our device has significant potential for use as a low-cost, high-performance, portable, and user-friendly FACS instrument.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.