Evidence map›Paper›PMID 26331880›Full record

ArticleAlcoholism, clinical and experimental research2015

Alcohol Administration Increases Cocaine Craving But Not Cocaine Cue Attentional Bias.

Katherine R Marks, Erika Pike, William W Stoops, Craig R Rush

Abstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katherine R MarksDepartment of Psychology, University of Kentucky College of Arts and Sciences, Lexington, Kentucky.
Erika PikeDepartment of Psychology, University of Kentucky College of Arts and Sciences, Lexington, Kentucky.
William W StoopsDepartment of Psychology, University of Kentucky College of Arts and Sciences, Lexington, Kentucky.
Craig R RushDepartment of Psychology, University of Kentucky College of Arts and Sciences, Lexington, Kentucky.

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
Research Training in Drug Abuse BehaviorT32DA035200 · NIDA · UNIVERSITY OF KENTUCKY · PI CRAIG R RUSH, William Walton Stoops · 2013 to 2026
$4.4M
Agonist Replacement Therapy for Methamphetamine Dependence: Human Lab StudiesR01DA025032 · NIDA · UNIVERSITY OF KENTUCKY · PI RUSH, CRAIG R · 2009 to 2013
$1.8M
GABAA Modulation as a Target for Developing Medications for Methamphetamine AbuseR01DA025591 · NIDA · UNIVERSITY OF KENTUCKY · PI RUSH, CRAIG R · 2008 to 2012
$1.4M
Kentucky Center for Clinical and Translational ScienceTL1TR000115 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$518k
NCATS NIH HHS TL1 TR000115NCATS NIH HHS UL1 TR000117NIDA NIH HHS R01 DA025032NIDA NIH HHS R01 DA025591NIDA NIH HHS T32 DA035200
6 · The paper itself

Abstract

backgroundAlcohol consumption is a known antecedent to cocaine relapse. Through associative conditioning, it is hypothesized that alcohol increases incentive motivation for cocaine and thus the salience of cocaine-related cues, which are important in maintaining drug-taking behavior. Cocaine-using individuals display a robust cocaine cue attentional bias as measured by fixation time during the visual probe task. The purpose of this study was to evaluate the influence of alcohol administration on cocaine cue attentional bias using eye-tracking technology to directly measure attentional allocation.

methodsTwenty current cocaine users completed a double-blind, placebo-controlled, within-subjects study that tested the effect of 3 doses of alcohol (0.00, 0.325, and 0.65 g/kg) on cocaine cue attentional bias using the visual probe task with eye-tracking technology. The participant-rated and physiological effects of alcohol were also assessed.

resultsParticipants displayed a robust cocaine cue attentional bias following both placebo and alcohol administration as measured by fixation time, but not response time. Alcohol administration did not influence cocaine cue attentional bias, but increased craving for cocaine in a dose-dependent manner. Alcohol produced prototypic psychomotor and participant-rated effects.

conclusionsAlcohol administration increases cocaine craving but not cocaine cue attentional bias. Alcohol-induced cocaine craving suggests that alcohol increases incentive motivation for cocaine but not the salience of cocaine-related cues.

Indexed as

CuesAdultAlcohol DrinkingAttentionCocaine-Related DisordersCravingDose-Response Relationship, DrugDouble-Blind MethodEthanolFemaleHumansMaleMiddle AgedPhotic StimulationPsychomotor PerformanceReaction TimeEthanolAlcoholAttentional BiasCocaineEye TrackingVisual Probe Task

Identifiers

PMID26331880
PMCPMC4562057

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.