ArticleJournal of exercise rehabilitation2015
Exhaustive submaximal endurance and resistance exercises induce temporary immunosuppression via physical and oxidative stress.
Article in Journal of exercise rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Effect ofNutrients · 2019Trial
- Transcriptomic time course of skeletal muscle disuse and rehabilitation in middle-aged adults.Physiological reports · 2025Article
- Immune consequences of exercise in hypoxia: A narrative review.Journal of sport and health science · 2024Review
- Physical Exercise Decreases Endoplasmic Reticulum Stress in Central and Peripheral Tissues of Rodents: A Systematic Review.European journal of investigation in health, psychology and education · 2023Review
- Endogenous and Exogenous Antioxidants in Skeletal Muscle Fatigue Development during Exercise.Antioxidants (Basel, Switzerland) · 2023Review
- Precious but convenient means of prevention and treatment: physiological molecular mechanisms of interaction between exercise and motor factors and Alzheimer's disease.Frontiers in physiology · 2023Review
- The effects of normobaric hypoxia on the leukocyte responses to resistance exercise.Biology of sport · 2023Article
- Physical Fitness and Inflammatory Response to the Training Load of Wheelchair Rugby Players.International journal of environmental research and public health · 2022Article
- Protective Effects of Exercise Become Especially Important for the Aging Immune System in The Covid-19 Era.Aging and disease · 2022Review
- Potential Role of Chronic Physical Exercise as a Treatment in the Development of Vitiligo.Frontiers in physiology · 2022Article
- The Role of Immune Cells in Oxi-Inflamm-Aging.Cells · 2021Review
- Beyond the Finish Line: The Impact and Dynamics of Biomarkers in Physical Exercise-A Narrative Review.Journal of clinical medicine · 2021Review
- Acute and Chronic Catabolic Responses toInternational journal of environmental research and public health · 2020Article
- Addressing a national crisis: the spine hospital and department's response to the COVID-19 pandemic in New York City.The spine journal : official journal of the North American Spine Society · 2020Article
- Gender Differences in Chronic Hormonal and Immunological Responses to CrossFitInternational journal of environmental research and public health · 2019Article
- Changes in Lymphocyte Composition and Functionality After Intensive Training and Exhausting Exercise in Rats.Frontiers in physiology · 2019Article
- The effects of combined aerobic and resistance training on inflammatory markers in obese men.Journal of exercise rehabilitation · 2018Article
- Aerobic but not Resistance Exercise Can Induce Inflammatory Pathways via Toll-Like 2 and 4: a Systematic Review.Sports medicine - open · 2017Review
- Redox Mechanism of Reactive Oxygen Species in Exercise.Frontiers in physiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledRegular running and strength training are the best ways to improve aerobic capacity and develop the size of skeletal muscles. However, uncontrolled physical activities can often lead to an undertraining or over-training syndrome. In particular, overtraining causes persistent fatigue and reduces physical performance due to changes in the various physiological and immunological factors. In this study, we gave an exhaustive submaximal endurance or resistance exercise to participants and investigated the relationship between physical stress (cortisol level in blood), oxidative stress (intracellular ROS accumulation), and adaptive immune response (CD4:CD8 ratio). MATERIALS AND
methodsTen male volunteers were recruited, and performed a submaximal endurance or resistance exercise with 85% of VO2max or 1-repetition maximum until exhaustion. Blood samples were collected at rest, and at 0 and 30 min after the exercise. Cortisol levels, oxidative stress, and immune cell phenotypes in peripheral blood were evaluated. Cortisol levels in the sera increased after the exhaustive endurance and resistance exercises and such increments were maintained through the recovery. Intra-cellular ROS levels also increased after the exhaustive endurance and resistance exercises. The ratio of CD4+ T cells to CD8+ T cells after each type of submaximal exercise decreased compared with that at the resting stage, and returned to the resting level at 30 min after the exercise. In this study, an exhaustive endurance or a resistance exercise with submaximal intensity caused excessive physical stress, intra-cellular oxidative stress, and post-exercise immunosuppression. This result suggests that excessive physical stress induced temporary immune dysfunction via physical and oxidative stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.