ReviewBiomaterials research2014
New approach for the treatment of osteoradionecrosis with pentoxifylline and tocopherol.
Review in Biomaterials research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 72 citations in OpenAlex.
- Article
- Machine Learning Models for Individualized Osteoradionecrosis Risk Prediction in Head and Neck Cancer.Journal of medical systems · 2026Article
- Review
- Senescence-driven osteonecrosis of the femoral head in the elderly-a distinct pathophysiological entity.Frontiers in medicine · 2025Article
- Current options in jaw and facial reconstructions.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2024Review
- Osteonecrosis of the Jaws: An Update and Review of Literature.Journal of maxillofacial and oral surgery · 2023Review
- Osteoradionecrosis of the jaw: A mini review.Frontiers in oral health · 2022Review
- Effects of Combination Treatments with Astaxanthin-Loaded Microparticles and Pentoxifylline on Intracellular ROS and Radiosensitivity of J774A.1 Macrophages.Molecules (Basel, Switzerland) · 2021Article
- Computed Tomography Radiomics Kinetics as Early Imaging Correlates of Osteoradionecrosis in Oropharyngeal Cancer Patients.Frontiers in artificial intelligence · 2021Article
- Osteoradionecrosis of the Maxilla: Conservative Management and Reconstructive Considerations.Seminars in plastic surgery · 2020Review
- Lumbar vertebral osteoradionecrosis: a rare case report with 10-year follow-up and brief literature review.BMC musculoskeletal disorders · 2020Review
- Effects of pentoxifylline and tocopherol on a rat-irradiated jaw model using micro-CT cortical bone analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Article
- Therapeutic efficacy of pentoxifylline on proteinuria and renal progression: an update.Journal of biomedical science · 2017Review
- In-vivo imaging of the microvasculature of the soft tissue margins of osteonecrotic jaw lesions.British dental journal · 2017Article
- Electron beam effect on biomaterials I: focusing on bone graft materials.Biomaterials research · 2015Article
- Osteoradionecrosis of Jaw: An Institutional Experience.Contemporary clinical dentistryArticle
- Prophylactic Use of Pentoxifylline and Tocopherol in Patients Undergoing Dental Extractions Following Radiotherapy for Head and Neck Cancer.Nigerian journal of surgery : official publication of the Nigerian Surgical Research SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoradionecrosis (ORN) of the jaw is a significant complication of radiotherapy for oral cavity cancer. In addition to antibiotic medication, treatment options such as hyperbaric oxygen therapy, surgical approaches, and combined therapy with pentoxifylline and tocopherol have been recently introduced. In this review article, we will discuss the definition and classifications of osteoradionecrosis, its etiology and pathophysiology, previous treatment options, oral and maxillofacial complications of radiotherapy, basic information on pentoxifylline and tocopherol, recent reports of pentoxifylline and tocopherol combined therapy, and, finally, ORN-induced animal models and future approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.