Preconcentration and Determination of Mefenamic Acid in Pharmaceutical and Biological Fluid Samples by Polymer-grafted Silica Gel Solid-phase Extraction Following High Performance Liquid Chromatography.

Hayedeh Bagheri Sadeghi, Homayon Ahmad Panahi, Mahsa Mahabadi, Elham Moniri

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Article in Iranian journal of pharmaceutical research : IJPR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

1.1field-weighted citation impact, top 21% of its field

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1 citing paper in PubMed, 7 citations in OpenAlex.

Preparation of Ethylene Glycol Dimethacrylate (EGDMA)-Based Terpolymer as Potential Sorbents for Pharmaceuticals Adsorption.Polymers · 2020
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4 authors at 2 institutions in 1 country.

Hayedeh Bagheri SadeghiDepartment of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

Homayon Ahmad PanahiDepartment of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

Mahsa MahabadiDepartment of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

Elham MoniriDepartment of Chemistry, Varamin (Pishva) Branch, Islamic Azad University, Varamin, Iran.

Islamic Azad University Central Tehran Branch · IRIslamic Azad University of Varamin · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that has analgesic, anti-infammatory and antipyretic actions. It is used to relieve mild to moderate pains. Solid-phase extraction of mefenamic acid by a polymer grafted to silica gel is reported. Poly allyl glycidyl ether/iminodiacetic acid-co-N, N-dimethylacrylamide was synthesized and grafted to silica gel and was used as an adsorbent for extraction of trace mefenamic acid in pharmaceutical and biological samples. Different factors affecting the extraction method were investigated and optimum conditions were obtained. The optimum pH value for sorption of mefenamic acid was 4.0. The sorption capacity of grafted adsorbent was 7.0 mg/g. The best eluent solvent was found to be trifluoroacetic acid-acetic acid in methanol with a recovery of 99.6%. The equilibrium adsorption data of mefenamic acid by grafted silica gel was analyzed by Langmuir model. The conformation of obtained data to Langmuir isotherm model reveals the homogeneous binding sites of grafted silica gel surface. Kinetic study of the mefenamic acid sorption by grafted silica gel indicates the good accessibility of the active sites in the grafted polymer. The sorption rate of the investigated mefenamic acid on the grafted silica gel was less than 5 min. This novel synthesized adsorbent can be successfully applied for the extraction of trace mefenamic acid in human plasma, urine and pharmaceutical samples.

Indexed as

Biological sampleHigh performance liquid chromatographyMefenamic acidPharmaceutical sampleSolid phase extraction

Identifiers

PMID26330865

PMCPMC4518105

OpenAlexW1936080107

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.