Evidence map›Paper›PMID 26330861›Full record

ArticleIranian journal of pharmaceutical research : IJPR2015

Reinvestigation of the Two-step Synthesis of Sevoflurane.

Abolghasem Moghimi, Mostafa Vojdani, Ali R Banan, Ahmad Mollaei, Mojtaba Mahmoodian, Sayyed Mojtaba Moosavi

Abstract read
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In one paragraph

Article in Iranian journal of pharmaceutical research : IJPR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abolghasem MoghimiDepartment of Chemistry, Imam Hossein University, Tehran, Iran.
Mostafa VojdaniDepartment of Chemistry, Imam Hossein University, Tehran, Iran. ; Department of Nuclear Medicine, The Educational, Research and Clinical Center, Dr. Masih Daneshvari Hospital, Tehran, Iran.
Ali R BananDepartment of Chemistry, Imam Hossein University, Tehran, Iran.
Ahmad MollaeiDepartment of Chemistry, Imam Hossein University, Tehran, Iran.
Mojtaba MahmoodianDepartment of Chemistry, Imam Hossein University, Tehran, Iran.
Sayyed Mojtaba MoosaviDepartment of Chemistry, Imam Hossein University, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Improvements in the two-step synthesis of 1,1,1,3,3,3-hexafluoro-2- (fluoromehoxy)propane (Sevoflurane) that result in the product cost reduction, safety level enhancement and positive environmental impacts are described. This process consists of chloromethylation reaction of 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) followed by a halogen-exchange fluorination. This is the first synthesis of Sevoflurane in Iran which was successfully scaled up. During this work, several improvements have been achieved by optimization of the reaction time, the amount of consumed starting materials and solvents and work up procedure while keeping the yield and purity intact. The reaction time of the first step (24 h) was diminished to 4 h. (19)F NMR spectroscopy was used to investigate the rate of the reaction in the first step and to evaluate the influence of different parameters mentioned on the achieved improvements.

Indexed as

Halogen-exchange fluorinationHexafluoro-2-propanolInhalation anestheticSevoflurane

Identifiers

PMID26330861
PMCPMC4518101

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.