ArticleIranian journal of pharmaceutical research : IJPR2015
Synthesis and Antibacterial Evaluation of New Thione Substituted 1,2,4-Triazole Schiff Bases as Novel Antimicrobial Agents.
Article in Iranian journal of pharmaceutical research : IJPR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- A Comprehensive Review on Synthetic Approaches and Antibacterial Activity Studies of 1,2,4-Triazole Derivatives over the Past Sixteen Years (2009-Present).Current organic synthesis · 2025Review
- 3D QSAR study on substituted 1, 2, 4 triazole derivatives as anticancer agents by kNN MFA approach.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Synthesis, Characterization and Biological Evaluation of Novel Benzamidine Derivatives: Newer Antibiotics for Periodontitis Treatment.Antibiotics (Basel, Switzerland) · 2022Article
- Design, Synthesis, and Antimicrobial Activity of Certain New Indole-1,2,4 Triazole Conjugates.Molecules (Basel, Switzerland) · 2021Article
- Synthesis and antibacterial and antiviral activities of myricetin derivatives containing a 1,2,4-triazole Schiff base.RSC advances · 2019Article
- Enhanced tumor delivery and antitumor response of doxorubicin-loaded albumin nanoparticles formulated based on a Schiff base.International journal of nanomedicine · 2016Article
- Novel Oxadiazole Thioglycosides as Potential Anti-Iranian journal of pharmaceutical research : IJPR · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The condensation reaction of 5-(4-aminophenyl)-4-phenyl-1,2,4-triazole-3-thione with salicylaldehyde, 4-hydroxybenzaldehyde, 5-chlorosalicylaldehyde, 5-bromosalicylaldehyde, 2-nitrobenzaldehyde, 3-nitrobenzaldehyde, 4-nitrobenzaldehyde and 4-methoxybenzaldehyde in methanol results in series of new Schiff bases. The structure of Schiff bases were confirmed by (1)H NMR, (13)C NMR, IR and mass spectroscopy. The synthesized compounds were tested for their antimicrobial activity against bacterial (Gram negative and Gram positive) strains in-vitro. The synthetic compounds showed different inhibition zones against tested bacterial strains. All compounds showed significant antiproliferative activity against Acinetobacter calcoaceticus ATCC 23055. In detail, Entrococcus faecalis (Gram positive) was resistant to all prepared compounds, whereas, A. calcoaceticus (Gram negative) was sensitive to all compounds especially 5c, 5d and 4. S. aureus (Gram positive, relatively resistant to antimicrobials) showed limited sensitivity to only 5c and 5d, and it was resistant to all other compounds and only 5c exhibited low activity against P. aeruginosa (Gram negative). The best results belonged to 5c that showed high activity against A. calcoaceticus (33 mm) as well as S. aureus (20 mm).
Indexed as
Identifiers
26330857PMC4518097W2105323533What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.