ArticleNeural regeneration research2015
Fibrin glue repair leads to enhanced axonal elongation during early peripheral nerve regeneration in an in vivo mouse model.
Article in Neural regeneration research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Comparison of Photochemically Sealed Commercial Biomembranes for Nerve Regeneration.Journal of functional biomaterials · 2025Article
- Photosealed Neurorrhaphy Using Autologous Tissue.International journal of molecular sciences · 2024Article
- Tensile strength of adhesives in peripheral nerve anastomoses: an in vitro biomechanical evaluation of four different neurorrhaphies.European journal of medical research · 2024Article
- Nerve Regeneration after a Nerve Graft in a Rat Model: The Effectiveness of Fibrin Glue.Journal of personalized medicine · 2024Article
- Functional recovery and muscle atrophy in pre-clinical models of peripheral nerve transection and gap-grafting in mice: effects of 4-aminopyridine.Neural regeneration research · 2023Article
- Medical Adhesives and Their Role in Laparoscopic Surgery-A Review of Literature.Materials (Basel, Switzerland) · 2022Review
- Angiogenesis is critical for the exercise-mediated enhancement of axon regeneration following peripheral nerve injury.Experimental neurology · 2022Article
- Purposeful Misalignment of Severed Nerve Stumps in a Standardized Transection Model Reveals Persistent Functional Deficit With Aberrant Neurofilament Distribution.Military medicine · 2021Article
- A novel nerve transection and repair method in mice: histomorphometric analysis of nerves, blood vessels, and muscles with functional recovery.Scientific reports · 2020Article
- Comparison of the Never Repair with Fibrin Glue and Perineural Micro-Suture in Rat Model.World journal of plastic surgery · 2020Article
- Current Status of Therapeutic Approaches against Peripheral Nerve Injuries: A Detailed Story from Injury to Recovery.International journal of biological sciences · 2020Review
- Sciatic Nerve Cut and Repair Using Fibrin Glue in Adult Mice.Bio-protocol · 2019Article
- Validation of a novel animal model for sciatic nerve repair with an adipose-derived stem cell loaded fibrin conduit.Neural regeneration research · 2018Article
- Fibrin glue as a stabilization strategy in peripheral nerve repair when using porous nerve guidance conduits.Journal of materials science. Materials in medicine · 2017Article
- Multiple uses of fibrin sealant for nervous system treatment following injury and disease.The journal of venomous animals and toxins including tropical diseases · 2017Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microsurgical suturing is the gold standard of nerve coaptation. Although literature on the usefulness of fibrin glue as an alternative is becoming increasingly available, it remains contradictory. Furthermore, no data exist on how both repair methods might influence the morphological aspects (arborization; branching) of early peripheral nerve regeneration. We used the sciatic nerve transplantation model in thy-1 yellow fluorescent protein mice (YFP; n = 10). Pieces of nerve (1cm) were grafted from YFP-negative mice (n = 10) into those expressing YFP. We performed microsuture coaptations on one side and used fibrin glue for repair on the contralateral side. Seven days after grafting, the regeneration distance, the percentage of regenerating and arborizing axons, the number of branches per axon, the coaptation failure rate, the gap size at the repair site and the time needed for surgical repair were all investigated. Fibrin glue repair resulted in regenerating axons travelling further into the distal nerve. It also increased the percentage of arborizing axons. No coaptation failure was detected. Gap sizes were comparable in both groups. Fibrin glue significantly reduced surgical repair time. The increase in regeneration distance, even after the short period of time, is in line with the results of others that showed faster axonal regeneration after fibrin glue repair. The increase in arborizing axons could be another explanation for better functional and electrophysiological results after fibrin glue repair. Fibrin glue nerve coaptation seems to be a promising alternative to microsuture repair.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.