ArticleJournal of anaesthesiology, clinical pharmacology
Physiological and pharmacologic aspects of peripheral nerve blocks.
Article in Journal of anaesthesiology, clinical pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06668116 (The Impact of Local Anesthetic Dilution on the Possibility of Blinding Studies Involving Peripheral Nerve Blocks. A Randomized, Prospective, Monocentric Study on Volunteers), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Local Anesthetic Dilution on the Possibility of Blinding Studies Involving Peripheral Nerve Blocks. A Randomized, Prospective, Monocentric Study on Volunteers
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Functional recovery with peripheral nerve block versus general anesthesia for upper limb surgery: a systematic review.BMC anesthesiology · 2023Pooled it
- A systematic review of the effect of regional anesthesia on diagnosis and management of acute compartment syndrome in long bone fractures.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Pooled it
- Effects of rhomboid intercostal and sub-serratus plane block on perioperative analgesic efficacy and diaphragm excursion in video-assisted thoracic surgery: a prospective, randomized controlled trial.BMC anesthesiology · 2025Trial
- Prophylactic intra-arterial injection of lidocaine: a novel strategy to prevent endovascular embolization-induced trigeminocardiac reflex.Journal of neurointerventional surgery · 2023Trial
- Comparison between two different concentrations of a fixed dose of ropivacaine in interscalene brachial plexus block for pain management after arthroscopic shoulder surgery: a randomized clinical trial.Korean journal of anesthesiology · 2021Trial
- Peripheral Nerve Stimulation Reduces Opioid Use and Facilitates Early Ambulation Following Fibular Flap Harvest: A Retrospective Study.Plastic and reconstructive surgery. Global open · 2026Article
- Comprehensive Assessment of Pain and Physiological Parameters of Sympathetic Blockade to Accurately Determine the Success of High Thoracic Erector Spinae Plane Block.Healthcare (Basel, Switzerland) · 2025Article
- An in vivo rat model for comparing selective blockade between sensory and motor nerve conduction.Scientific reports · 2025Article
- Comparative study of epidural ropivacaine and bupivacaine with fentanyl in abdominal surgery.Bioinformation · 2025Article
- Alkamides inInternational journal of molecular sciences · 2024Review
- Novel Techniques for Musculoskeletal Pain Management after Orthopedic Surgical Procedures: A Systematic Review.Life (Basel, Switzerland) · 2023Review
- "Knowing It Before Blocking It," the ABCD of the Peripheral Nerves: Part A (Nerve Anatomy and Physiology).Cureus · 2023Review
- Regional anesthesia and analgesia in sickle cell pain episodes: A scoping review.Interventional pain medicine · 2022Article
- Easy to treat when the diagnosis is made: Three cases of clunealgia and the advantage of ultrasonography.Turkish journal of physical medicine and rehabilitation · 2022Article
- Quadrant and Dermatomal Analysis of Sensorial Block in Ultrasound- Guided Erector Spinae Plane Block.The Eurasian journal of medicine · 2022Article
- fNIRS brain measures of ongoing nociception during surgical incisions under anesthesia.Neurophotonics · 2022Article
- Article
- Spinal Dorsal Rami Injection and Radiofrequency Neurolysis for Low Back Pain Caused by Osteoporosis-Induced Thoracolumbar Vertebral Compression Fractures.Journal of rehabilitation medicine. Clinical communications · 2021Article
- Intra-Arterial Lidocaine Blunts the Trigeminocardiac Reflex during Endovascular Treatment of a Carotid-Cavernous Fistula.Case reports in anesthesiology · 2021Article
- Co-Application of Eugenol and QX-314 Elicits the Prolonged Blockade of Voltage-Gated Sodium Channels in Nociceptive Trigeminal Ganglion Neurons.Biomolecules · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A successful peripheral nerve block not only involves a proper technique, but also a thorough knowledge and understanding of the physiology of nerve conduction and pharmacology of local anesthetics (LAs). This article focuses on what happens after the block. Pharmacodynamics of LAs, underlying mechanisms of clinically observable phenomena such as differential blockade, tachyphylaxis, C fiber resistance, tonic and phasic blockade and effect of volume and concentration of LAs. Judicious use of additives along with LAs in peripheral nerve blocks can prolong analgesia. An entirely new group of drugs-neurotoxins has shown potential as local anesthetics. Various methods are available now to prolong the duration of peripheral nerve blocks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.