ReviewTransactions of the American Clinical and Climatological Association2015
Chronic Pain: Where the Body Meets the Brain.
Review in Transactions of the American Clinical and Climatological Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 103 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of the Transition of the Foot Strike Pattern From Rearfoot to Midfoot or Forefoot During Running on Pain and Disability in Cadets With Chronic Musculoskeletal Pain
Effectiveness of Coping Strategies on the Control of Musculoskeletal Chronic Non-Cancer Pain and Quality of Life: A Randomized Clinical Trial
Toward Personalized Treatment of Chronic Pain Using Transcranial Direct Current Stimulation Paired With Deep Learning
Chronic Postsurgical Pain: Multivariate Prediction Model
Who cites it
103 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The bodily self in fibromyalgia: A systematic review and meta-analysis of body image, body representation, and interoceptive dysfunction.Psychiatry and clinical neurosciences · 2026Pooled it
- Dance for Chronic Pain Conditions: A Systematic Review.Pain medicine (Malden, Mass.) · 2022Pooled it
- Autogenic Training for Reducing Chronic Pain: a Systematic Review and Meta-analysis of Randomized Controlled Trials.International journal of behavioral medicine · 2022Pooled it
- The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain.Nutrients · 2022Pooled it
- A Systematic Review and Meta-Analysis of Efficacy of Botulinum Toxin A for Neuropathic Pain.Toxins · 2022Pooled it
- Targeted limbic self-neuromodulation for alleviating central sensitization symptoms in fibromyalgia.BMC medicine · 2025Trial
- miR-217-5p Regulates Microglia-Related Neuroinflammation via NF1 and Further Modulates Chronic Constriction Injury-Induced Neuropathic Pain.Molecular neurobiology · 2026Article
- Daily Associations Between Perceived Stress, Pain Intensity, and Alcohol Use Among Veterans With and Without Moderate-to-Severe Chronic Pain.Stress and health : journal of the International Society for the Investigation of Stress · 2026Article
- Neuroimaging-Guided Insights into the Molecular and Network Mechanisms of Chronic Pain and Neuromodulation.International journal of molecular sciences · 2026Review
- Impact of remote learning on posture and musculoskeletal health among Sudanese medical students during the 2023-2024 conflict: a cross-sectional study.BMC musculoskeletal disorders · 2026Article
- Drug Polymer Nanoparticles: An Advancement in Biomedical Solutions and Targeted Drug Delivery.Drug design, development and therapy · 2026Review
- Heart rate variability and pain sensitivity in people with chronic shoulder pain during passive viewing of shoulder movement pictures.PloS one · 2026Article
- Biotinidase as a novel biomarker for pain assessment in dairy cattle.Pain reports · 2025Article
- Women's experiences of living with chronic pain: A qualitative meta-synthesis.British journal of health psychology · 2025Article
- Prevalence of radiographic knee osteoarthritis in China: a national survey of thirty thousand, four hundred and fifty five individuals cross-sectional study.International orthopaedics · 2025Article
- The Effect of Physical Exercise on Non-Oncological Musculoskeletal Chronic Pain and Its Associated Biomarkers: Systematic Review on Randomized Controlled Trials.Life (Basel, Switzerland) · 2025Review
- Evaluating the Effects of a Progressive Kinesiotaping Treatment Protocol on Chronic Low Back Pain in Women Using Electroencephalography.Journal of functional morphology and kinesiology · 2025Article
- Pain Acceptance in Adolescent Chronic Pain: Do Body Mindsets Play a Role?The Clinical journal of pain · 2025Article
- Role of ncRNAs in the Development of Chronic Pain.Non-coding RNA · 2025Review
- Physical and Mental Health of Fibromyalgia Patients Following October 7th Attack and the Ensuing Military Conflict: A Cross-Sectional Analysis.European journal of pain (London, England) · 2025Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic musculoskeletal pain is one of the most intractable clinical problems faced by clinicians and can be devastating for patients. Central pain amplification is perceived pain that cannot be fully explained on the basis of somatic or neuropathic processes and is due to physiologic alterations in pain transmission or descending pain modulatory pathways. In any individual, central pain amplification may complicate nociceptive or neuropathic pain. Furthermore, patients with somatic symptom disorders may have alterations in their psychological or behavioral responses to pain that contribute significantly to the clinical presentation. Genetic, physiologic, and psychological factors associated with central pain amplification are beginning to be understood. One important contributor to chronic pain is perceived stress and stress response systems. We and others have shown a complex relationship between the physiologic stress response and chronic pain symptoms. Unfortunately, treatments for chronic pain are woefully inadequate and often worsen clinical outcomes. Developing new treatment strategies for patients with chronic pain is of utmost urgency. This essay provides a framework for thinking about chronic pain and developing new treatment approaches.
Indexed as
Identifiers
26330672PMC4530716What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.