Evidence map›Paper›PMID 26330563›Full record

ArticleNeuro-oncology2016

Efficacy of systemic adoptive transfer immunotherapy targeting NY-ESO-1 for glioblastoma.

Richard G Everson, Joseph P Antonios, Dominique N Lisiero, Horacio Soto, Rudi Scharnweber, Matthew C Garrett, William H Yong, Ning Li, Gang Li, Carol A Kruse and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 43 citations in OpenAlex.

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  11. Frontiers in immunology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Richard G EversonDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California (R.G.E., J.P.A., D.N.L., H.S., R.S., M.C.G., C.A.K., L.M.L., R.M.P.); Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California (D.N.L., R.M.P.); Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California (W.H.Y.); Department of Biostatistics, University of California Los Angeles, Los Angeles, California (N.L., G.L.); Brain Research Institute, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.); Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.).
Joseph P AntoniosDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California (R.G.E., J.P.A., D.N.L., H.S., R.S., M.C.G., C.A.K., L.M.L., R.M.P.); Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California (D.N.L., R.M.P.); Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California (W.H.Y.); Department of Biostatistics, University of California Los Angeles, Los Angeles, California (N.L., G.L.); Brain Research Institute, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.); Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.).
Dominique N LisieroDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California (R.G.E., J.P.A., D.N.L., H.S., R.S., M.C.G., C.A.K., L.M.L., R.M.P.); Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California (D.N.L., R.M.P.); Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California (W.H.Y.); Department of Biostatistics, University of California Los Angeles, Los Angeles, California (N.L., G.L.); Brain Research Institute, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.); Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.).
Horacio SotoDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California (R.G.E., J.P.A., D.N.L., H.S., R.S., M.C.G., C.A.K., L.M.L., R.M.P.); Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California (D.N.L., R.M.P.); Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California (W.H.Y.); Department of Biostatistics, University of California Los Angeles, Los Angeles, California (N.L., G.L.); Brain Research Institute, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.); Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.).
Rudi ScharnweberDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California (R.G.E., J.P.A., D.N.L., H.S., R.S., M.C.G., C.A.K., L.M.L., R.M.P.); Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California (D.N.L., R.M.P.); Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California (W.H.Y.); Department of Biostatistics, University of California Los Angeles, Los Angeles, California (N.L., G.L.); Brain Research Institute, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.); Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.).
Matthew C GarrettDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California (R.G.E., J.P.A., D.N.L., H.S., R.S., M.C.G., C.A.K., L.M.L., R.M.P.); Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California (D.N.L., R.M.P.); Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California (W.H.Y.); Department of Biostatistics, University of California Los Angeles, Los Angeles, California (N.L., G.L.); Brain Research Institute, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.); Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.).
William H YongDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California (R.G.E., J.P.A., D.N.L., H.S., R.S., M.C.G., C.A.K., L.M.L., R.M.P.); Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California (D.N.L., R.M.P.); Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California (W.H.Y.); Department of Biostatistics, University of California Los Angeles, Los Angeles, California (N.L., G.L.); Brain Research Institute, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.); Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.).
Ning LiDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California (R.G.E., J.P.A., D.N.L., H.S., R.S., M.C.G., C.A.K., L.M.L., R.M.P.); Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California (D.N.L., R.M.P.); Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California (W.H.Y.); Department of Biostatistics, University of California Los Angeles, Los Angeles, California (N.L., G.L.); Brain Research Institute, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.); Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.).
Gang LiDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California (R.G.E., J.P.A., D.N.L., H.S., R.S., M.C.G., C.A.K., L.M.L., R.M.P.); Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California (D.N.L., R.M.P.); Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California (W.H.Y.); Department of Biostatistics, University of California Los Angeles, Los Angeles, California (N.L., G.L.); Brain Research Institute, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.); Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.).
Carol A KruseDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California (R.G.E., J.P.A., D.N.L., H.S., R.S., M.C.G., C.A.K., L.M.L., R.M.P.); Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California (D.N.L., R.M.P.); Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California (W.H.Y.); Department of Biostatistics, University of California Los Angeles, Los Angeles, California (N.L., G.L.); Brain Research Institute, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.); Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.).
Linda M LiauDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California (R.G.E., J.P.A., D.N.L., H.S., R.S., M.C.G., C.A.K., L.M.L., R.M.P.); Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California (D.N.L., R.M.P.); Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California (W.H.Y.); Department of Biostatistics, University of California Los Angeles, Los Angeles, California (N.L., G.L.); Brain Research Institute, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.); Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.).
Robert M PrinsDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California (R.G.E., J.P.A., D.N.L., H.S., R.S., M.C.G., C.A.K., L.M.L., R.M.P.); Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California (D.N.L., R.M.P.); Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California (W.H.Y.); Department of Biostatistics, University of California Los Angeles, Los Angeles, California (N.L., G.L.); Brain Research Institute, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.); Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California (C.A.K., L.M.L., R.M.P.).
University of California, Los Angeles · USLos Angeles Medical Center · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Adoptive Transfer of AlloCTL for Immunotherapy of Recurrent GliomasR01CA125244 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIAU, LINDA M · 2010 to 2014
$2.4M
Optimizing Induction Conditions for Immunotherapeutic CTLR01CA154256 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PRINS, ROBERT M · 2010 to 2014
$1.9M
Dendritic Cell Vaccine Targeting Melanoma-Associated Antigens in Malignant GliomaR01CA112358 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIAU, LINDA M · 2006 to 2010
$1.3M
UCLA Neurosurgery Research Training and Education ProgramR25NS079198 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIAU, LINDA M · 2012 to 2021
$1.2M
CNS Anti-tumor immunity induced by dendritic cell vaccination and TLR agonistsR01CA123396 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PRINS, ROBERT M · 2007 to 2010
$939k
Immune targeting of melanoma-associated antigens in gliomaK01CA111402 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PRINS, ROBERT M · 2006 to 2010
$705k
Immunotherapeutic targeting of the Glioblastoma MutanomeR21CA186004 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARGAESPADA, DAVID ANDREW, PRINS, ROBERT M · 2015 to 2016
$380k
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCI NIH HHS K01-CA111402NCI NIH HHS P30 CA016042NCI NIH HHS P30-CA16042NCI NIH HHS R01-CA112358NCI NIH HHS R01-CA123396NCI NIH HHS R01-CA125244NCI NIH HHS R01 CA154256NCI NIH HHS R21 CA186004NINDS NIH HHS R25 NS079198
6 · The paper itself

Abstract

backgroundImmunotherapy is an ideal treatment modality to specifically target the diffusely infiltrative tumor cells of malignant gliomas while sparing the normal brain parenchyma. However, progress in the development of these therapies for glioblastoma has been slow due to the lack of immunogenic antigen targets that are expressed uniformly and selectively by gliomas.

methodsWe utilized human glioblastoma cell cultures to induce expression of New York-esophageal squamous cell carcinoma (NY-ESO-1) following in vitro treatment with the demethylating agent decitabine. We then investigated the phenotype of lymphocytes specific for NY-ESO-1 using flow cytometry analysis and cytotoxicity against cells treated with decitabine using the xCelligence real-time cytotoxicity assay. Finally, we examined the in vivo application of this immune therapy using an intracranially implanted xenograft model for in situ T cell trafficking, survival, and tissue studies.

resultsOur studies showed that treatment of intracranial glioma-bearing mice with decitabine reliably and consistently induced the expression of an immunogenic tumor-rejection antigen, NY-ESO-1, specifically in glioma cells and not in normal brain tissue. The upregulation of NY-ESO-1 by intracranial gliomas was associated with the migration of adoptively transferred NY-ESO-1-specific lymphocytes along white matter tracts to these tumors in the brain. Similarly, NY-ESO-1-specific adoptive T cell therapy demonstrated antitumor activity after decitabine treatment and conferred a highly significant survival benefit to mice bearing established intracranial human glioma xenografts. Transfer of NY-ESO-1-specific T cells systemically was superior to intracranial administration and resulted in significantly extended and long-term survival of animals.

conclusionThese results reveal an innovative, clinically feasible strategy for the treatment of glioblastoma.

Indexed as

Immunotherapy, AdoptiveAnimalsAntigens, NeoplasmAzacitidineCell Line, TumorDecitabineDisease Models, AnimalGlioblastomaHumansMiceT-LymphocytesAntigens, NeoplasmAzacitidineDecitabinecancerdecitabineengineered T cellsglioblastomaimmunotherapy

Identifiers

PMID26330563
PMCPMC4767237
OpenAlexW1841011077

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.