Evidence map›Paper›PMID 26330204›Full record

SynthesisEpidemiology and infection2016

Low-dose aspirin use does not diminish the immune response to monovalent H1N1 influenza vaccine in older adults.

M L Jackson, A Bellamy, M Wolff, H Hill, L A Jackson

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Epidemiology and infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

M L JacksonGroup Health Research Institute,Seattle,WA,USA.
A BellamyThe EMMES Corporation,Rockville MD,USA.
M WolffThe EMMES Corporation,Rockville MD,USA.
H HillThe EMMES Corporation,Rockville MD,USA.
L A JacksonGroup Health Research Institute,Seattle,WA,USA.
Emmes (United States) · USKaiser Permanente Washington Health Research Institute · US

Funding

NIAID NIH HHS HHSN272200800004CPHS HHS HHSN272200800004C
6 · The paper itself

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) may inhibit antibody production by peripheral blood mononuclear cells; one consequence of this could be decreased effectiveness of vaccines in NSAID users. Because many older adults use low-dose aspirin for primary or secondary prevention of coronary events, any inhibitory effect of aspirin on vaccine immune response could reduce the benefits of vaccination programmes in older adults. We tested whether immune response to vaccination differed between users vs. non-users of low-dose aspirin, using data from four randomized trials of monovalent 2009 pandemic influenza A(H1N1) vaccine. Geometric mean haemagglutination inhibition antibody titres were not significantly lower in low-dose aspirin users compared to non-users. Our results provide reassurance that influenza vaccination effectiveness is probably not reduced in older adults taking chronic low-dose aspirin.

Indexed as

AgedAnimalsAntibodies, ViralAnti-Inflammatory Agents, Non-SteroidalAspirinDogsDose-Response Relationship, DrugHumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanInfluenza VaccinesMiddle AgedAntibodies, ViralAnti-Inflammatory Agents, Non-SteroidalAspirinInfluenza VaccinesAnti-inflammatory agentshuman influenzanon-steroidalvaccines

Identifiers

PMID26330204
PMCPMC4737981
OpenAlexW2257754200

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.