ArticleCritical care (London, England)2015
Predictors for mechanical ventilation and short-term prognosis in patients with Guillain-Barré syndrome.
Article in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Guidelines for Neuroprognostication in Adults with Guillain-Barré Syndrome.Neurocritical care · 2023Guideline
- Patient Outcomes Among Medicare Beneficiaries With Guillain-Barré Syndrome.Journal of the peripheral nervous system : JPNS · 2026Article
- Predictors of respiratory decline in neuromuscular disorders.Respiratory medicine · 2026Review
- Prognostic Nutritional Index as a Biomarker of Disease Severity and Long-Term Outcome in Guillain-Barré Syndrome.Journal of the peripheral nervous system : JPNS · 2025Observational
- Correlation between elevated blood and cerebrospinal fluid glucose levels and the severity and short-term prognosis of Guillain-Barré syndrome.Acta neurologica Belgica · 2025Article
- Clinical study of the relationship between hepatitis B core antibody and mechanical ventilation in patients with Guillain-Barré syndrome.Frontiers in neurology · 2025Article
- Predictive assessment with outcomes of phrenic nerve study in Guillain-Barré syndrome: a prospective study.Journal of Yeungnam medical science · 2025Article
- Assessing the impact of a second IVIG dose on patients with Guillain-Barré Syndrome: A synthesis without meta-analysis (SWiM).Qatar medical journal · 2025Review
- Article
- Interpretable Machine Learning Model for Predicting the Prognosis of Guillain-Barré Syndrome Patients.Journal of inflammation research · 2024Article
- Clinical predictors for mechanical ventilation assistance in Guillain-Barré syndrome.Frontiers in neurology · 2024Article
- Risk Factors for Mechanical Ventilation in Patients with Guillain-Barré Syndrome.Neurocritical care · 2022Article
- International Validation of the Erasmus Guillain-Barré Syndrome Respiratory Insufficiency Score.Annals of neurology · 2022Article
- Increased systemic immune-inflammation index can predict respiratory failure in patients with Guillain-Barré syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Article
- Clinical Features and Outcome of the Guillain-Barre Syndrome: A Single-Center 11-Year Experience.Frontiers in neurology · 2022Article
- Guillain-Barré Syndrome Presenting as Facial Diplegia after COVID-19 Vaccination: A Case Report.The Journal of emergency medicine · 2021Article
- Predicting Mechanical Ventilation Using the EGRIS in Guillain-Barré Syndrome in a Latin American Country.Neurocritical care · 2021Article
- Prognostic Factors in Elderly Patients With Guillain-Barré Syndrome: Does Age Matter?The Neurohospitalist · 2021Article
- Clinical value of C-reactive protein/albumin ratio in Guillain-Barré syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGuillain-Barré syndrome (GBS) is an immune-mediated disorder of the peripheral nervous system. Respiratory failure requiring mechanical ventilation (MV) is a serious complication of GBS. Identification of modifiable risk factors for MV and poor short-term prognosis in mechanically ventilated patients with GBS may contribute to the individualized management and may help improve the outcome of the patients.
methodsWe retrospectively analyzed the clinical data of 541 patients who were diagnosed with GBS from 2003 to 2014. Independent predictors for MV and short-term prognosis in mechanically ventilated patients were identified via multivariate logistic regression analysis.
resultsThe mean age was 41.6 years with a male predilection (61.2%). Eighty patients (14.8%) required MV. Multivariate analysis revealed that shorter interval from onset to admission (p < 0.05), facial nerve palsy (p < 0.01), glossopharyngeal and vagal nerve deficits (p < 0.01) and lower Medical Research Council (MRC) sum score at nadir (p < 0.01) were risk factors for MV; disease occurrence in summer (p < 0.01) was a protective factor. As to prognostic factors, absence of antecedent infections (p < 0.01) and lower MRC sum score at nadir (p < 0.01) were predictors of poor short-term prognosis in mechanically ventilated patients regardless of treatment modality. We further investigated the predictors of poor short-term prognosis in patients requiring MV with different nadir MRC sum scores. Combined use of intravenous corticosteroids with intravenous immunoglobulin (odds ratio 10.200, 95% confidence interval 1.068-97.407, p < 0.05) was an independent predictor of poor short-term prognosis in mechanically ventilated patients with a nadir MRC sum score from 0 to 12 points, regardless of existence of antecedent infection.
conclusionsClinical predictors of MV and poor short-term prognosis in mechanically ventilated GBS patients were distinct. Add-on use of intravenous corticosteroids was a risk factor for poor short-term prognosis in mechanically ventilated patients with a nadir MRC sum score from 0 to 12 points.
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