ArticleBiological research2015
Inhibition of Rho-associated kinases disturbs the collective cell migration of stratified TE-10 cells.
Article in Biological research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- KTX207-mediated PDE4D degradation disrupts tumour cell migration, invasion, and angiogenic potential.Cell communication and signaling : CCS · 2026Article
- Rho-associated kinase regulates Langerhans cell morphology and responsiveness to tissue damage.Cell reports · 2024Article
- Multiscale nature of cell rearrangement caused by collective cell migration.European biophysics journal : EBJ · 2021Review
- Viscoelasticity of multicellular systems caused by collective cell migration: dynamics at the biointerface.European biophysics journal : EBJ · 2020Article
- The migration and fusion events related to ROCK activity strongly influence the morphology of chicken embryo intestinal organoids.Protoplasma · 2019Article
- Jamming state transition and collective cell migration.Journal of biological engineering · 2019Article
- Functional Epithelium Remodeling in Response to Applied Stress underApplied bionics and biomechanics · 2019Article
- Epithelial cell migration as a potential therapeutic target in early lung cancer.European respiratory review : an official journal of the European Respiratory Society · 2017Review
- Involvement of cAMP in the Human Serum-Induced Migration of Adipose-Derived Stem Cells.Development & reproduction · 2016Article
- The interaction between Staphylococcus aureus SdrD and desmoglein 1 is important for adhesion to host cells.Scientific reports · 2016Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe collective cell migration of stratified epithelial cells is considered to be an important phenomenon in wound healing, development, and cancer invasion; however, little is known about the mechanisms involved. Furthermore, whereas Rho family proteins, including RhoA, play important roles in cell migration, the exact role of Rho-associated coiled coil-containing protein kinases (ROCKs) in cell migration is controversial and might be cell-type dependent. Here, we report the development of a novel modified scratch assay that was used to observe the collective cell migration of stratified TE-10 cells derived from a human esophageal cancer specimen.
resultsDesmosomes were found between the TE-10 cells and microvilli of the surface of the cell sheet. The leading edge of cells in the cell sheet formed a simple layer and moved forward regularly; these rows were followed by the stratified epithelium. ROCK inhibitors and ROCK small interfering RNAs (siRNAs) disturbed not only the collective migration of the leading edge of this cell sheet, but also the stratified layer in the rear. In contrast, RhoA siRNA treatment resulted in more rapid migration of the leading rows and disturbed movement of the stratified portion.
conclusionsThe data presented in this study suggest that ROCKs play an important role in mediating the collective migration of TE-10 cell sheets. In addition, differences between the effects of siRNAs targeting either RhoA or ROCKs suggested that distinct mechanisms regulate the collective cell migration in the simple epithelium of the wound edge versus the stratified layer of the epithelium.
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