ArticleScientific reports2015
Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- Can Photoacoustic Imaging Provide a Sensitive Marker for Early Detection of Diabetic Nephropathy.Journal of biophotonics · 2026Article
- APLNR reduction in kidney-muscle crosstalk in renal model recovered by exercise and STAT3 inhibition.Biochemistry and biophysics reports · 2026Article
- Multiparametric MRI based assessment of kidney injury in a mouse model of ischemia reperfusion injury.Scientific reports · 2024Article
- Ergothioneine promotes longevity and healthy aging in male mice.GeroScience · 2024Article
- Transcutaneous measurement of renal function in two rodent models of obstructive nephropathy.BMC research notes · 2023Article
- Methods for Assessment of the Glomerular Filtration Rate in Laboratory Animals.Kidney diseases (Basel, Switzerland) · 2022Review
- Spatial quantification of clinical biomarker pharmacokinetics through deep learning-based segmentation and signal-oriented analysis of MSOT data.Photoacoustics · 2022Article
- Murine models of renal ischemia reperfusion injury: An opportunity for refinement using noninvasive monitoring methods.Physiological reports · 2022Article
- A Review of Specific Biomarkers of Chronic Renal Injury and Their Potential Application in Nonclinical Safety Assessment Studies.Toxicologic pathology · 2021Review
- DHHC21 deficiency attenuates renal dysfunction during septic injury.Scientific reports · 2021Article
- The complex interplay between kidney injury and inflammation.Clinical kidney journal · 2021Review
- Complement Properdin Determines Disease Activity in MRL/Medicina (Kaunas, Lithuania) · 2020Article
- Stem cell delivery to kidney via minimally invasive ultrasound-guided renal artery injection in mice.Scientific reports · 2020Article
- A Novel Hybrid Cytokine IL233 Mediates regeneration following Doxorubicin-Induced Nephrotoxic Injury.Scientific reports · 2019Article
- A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction.Stem cells international · 2019Article
- Molecular Photoacoustic Contrast Agents: Design Principles & Applications.Photochemistry and photobiology · 2018Review
- Small Molecule Optoacoustic Contrast Agents: An Unexplored Avenue for Enhancing In Vivo Imaging.Molecules (Basel, Switzerland) · 2018Review
- Transdermal Measurement of Glomerular Filtration Rate in Mice.Journal of visualized experiments : JoVE · 2018Article
- Noninvasive Real-Time Characterization of Renal Clearance Kinetics in Diabetic Mice after Receiving Danshensu Treatment.Oxidative medicine and cellular longevity · 2018Article
- Constrained Inversion and Spectral Unmixing in Multispectral Optoacoustic Tomography.IEEE transactions on medical imaging · 2017Article
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Authors and funding
17 authors at 4 institutions in 3 countries.
Funding
Abstract
Maximising the use of preclinical murine models of progressive kidney disease as test beds for therapies ideally requires kidney function to be measured repeatedly in a safe, minimally invasive manner. To date, most studies of murine nephropathy depend on unreliable markers of renal physiological function, exemplified by measuring blood levels of creatinine and urea, and on various end points necessitating sacrifice of experimental animals to assess histological damage, thus counteracting the principles of Replacement, Refinement and Reduction. Here, we applied two novel minimally invasive techniques to measure kidney function in SCID mice with adriamycin-induced nephropathy. We employed i) a transcutaneous device that measures the half-life of intravenously administered FITC-sinistrin, a molecule cleared by glomerular filtration; and ii) multispectral optoacoustic tomography, a photoacoustic imaging device that directly visualises the clearance of the near infrared dye, IRDye 800CW carboxylate. Measurements with either technique showed a significant impairment of renal function in experimental animals versus controls, with significant correlations with the proportion of scarred glomeruli five weeks after induction of injury. These technologies provide clinically relevant functional data and should be widely adopted for testing the efficacies of novel therapies. Moreover, their use will also lead to a reduction in experimental animal numbers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.