ArticleJournal of biomechanics2015
Hemodynamic and thrombogenic analysis of a trileaflet polymeric valve using a fluid-structure interaction approach.
Article in Journal of biomechanics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Computational Fluid Dynamics Assessment Associated with Transcatheter Heart Valve Prostheses: A Position Paper of the ISO Working Group.Cardiovascular engineering and technology · 2018Guideline
- Hematologic complications and design challenges in cardiovascular devices.Communications engineering · 2026Review
- Effect of Initial Opening Morphology of Polymeric Valves on Hemodynamic Performance.Cardiovascular engineering and technology · 2025Article
- Thrombogenic Risk Assessment of Transcatheter Prosthetic Heart Valves Using a Fluid-Structure Interaction Approach.Computer methods and programs in biomedicine · 2024Article
- Article
- Strategies for Development of Synthetic Heart Valve Tissue Engineering Scaffolds.Progress in materials science · 2023Article
- Analysis of the Effect of Thickness on the Performance of Polymeric Heart Valves.Journal of functional biomaterials · 2023Article
- A Doppler-exclusive non-invasive computational diagnostic framework for personalized transcatheter aortic valve replacement.Scientific reports · 2023Article
- Polymeric Heart Valves Will Displace Mechanical and Tissue Heart Valves: A New Era for the Medical Devices.International journal of molecular sciences · 2023Review
- Polymeric prosthetic heart valves: A review of current technologies and future directions.Frontiers in cardiovascular medicine · 2023Review
- Visions of TAVR Future: Development and Optimization of a Second Generation Novel Polymeric TAVR.Journal of biomechanical engineering · 2022Article
- A Single-opening&closing Valve Tester for Direct Measurement of Closing Volume of the Heart Valve.Cardiovascular engineering and technology · 2022Article
- Shear-mediated platelet activation in the free flow II: Evolving mechanobiological mechanisms reveal an identifiable signature of activation and a bi-directional platelet dyscrasia with thrombotic and bleeding features.Journal of biomechanics · 2021Review
- New Insights into Valve Hemodynamics.Rambam Maimonides medical journal · 2020Review
- In Vitro Durability and Stability Testing of a Novel Polymeric Transcatheter Aortic Valve.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020Article
- Mechanical considerations for polymeric heart valve development: Biomechanics, materials, design and manufacturing.Biomaterials · 2019Review
- Principles of TAVR valve design, modelling, and testing.Expert review of medical devices · 2018Review
- Microfluidic flow-based platforms for induction and analysis of dynamic shear-mediated platelet activation-Initial validation versus the standardized hemodynamic shearing device.Biomicrofluidics · 2018Article
- Original article submission: Platelet stress accumulation analysis to predict thrombogenicity of an artificial kidney.Journal of biomechanics · 2018Article
- Microfludic platforms for the evaluation of anti-platelet agent efficacy under hyper-shear conditions associated with ventricular assist devices.Medical engineering & physics · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Surgical valve replacement in patients with severe calcific aortic valve disease using either bioprosthetic or mechanical heart valves is still limited by structural valve deterioration for the former and thrombosis risk mandating anticoagulant therapy for the latter. Prosthetic polymeric heart valves have the potential to overcome the inherent material and design limitations of these valves, but their development is still ongoing. The aim of this study was to characterize the hemodynamics and thrombogenic potential of the Polynova polymeric trileaflet valve prototype using a fluid-structure interaction (FSI) approach. The FSI model replicated experimental conditions of the valve as tested in a left heart simulator. Hemodynamic parameters (transvalvular pressure gradient, flow rate, maximum velocity, and effective orifice area) were compared to assess the validity of the FSI model. The thrombogenic footprint of the polymeric valve was evaluated using a Lagrangian approach to calculate the stress accumulation (SA) values along multiple platelet trajectories and their statistical distribution. In the commissural regions, platelets were exposed to the highest SA values because of highest stress levels combined with local reverse flow patterns and vortices. Stress-loading waveforms from representative trajectories in regions of interest were emulated in our hemodynamic shearing device (HSD). Platelet activity was measured using our platelet activation state (PAS) assay and the results confirmed the higher thrombogenic potential of the commissural hotspots. In conclusion, the proposed method provides an in depth analysis of the hemodynamic and thrombogenic performance of the polymer valve prototype and identifies locations for further design optimization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.