Evidence map›Paper›PMID 26329340›Full record

ArticleThe Journal of rheumatology2015

Insulin-like Growth Factor 1 and Adiponectin and Associations with Muscle Deficits, Disease Characteristics, and Treatments in Rheumatoid Arthritis.

Joshua F Baker, Joan Marie Von Feldt, Sogol Mostoufi-Moab, Woojin Kim, Elena Taratuta, Mary B Leonard

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of rheumatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Insulin-like growth factor receptor signaling in physiology and disease.Signal transduction and targeted therapy · 2026
    Review
  3. Article
  4. Observational
  5. Review
  6. Review
  7. Article
  8. Analysis of the adiponectin paradox in healthy older people.Journal of cachexia, sarcopenia and muscle · 2023
    Article
  9. Article
  10. Article
  11. Adiponectin Deregulation in Systemic Autoimmune Rheumatic Diseases.International journal of molecular sciences · 2021
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. The Adiponectin Paradox in the Elderly: Associations With Body Composition, Physical Functioning, and Mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Observational
  18. IGF1 receptor and thyroid-associated ophthalmopathy.Journal of molecular endocrinology · 2018
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joshua F BakerFrom the Division of Rheumatology, Philadelphia Veteran Affairs (VA) Medical Center; Division of Rheumatology, and Department of Biostatistics and Epidemiology, and Children's Hospital of Philadelphia, Department of Pediatrics, and Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Pediatrics and Medicine, Stanford University, Stanford, California, USA.J.F. Baker, MD, MSCE, Division of Rheumatology, Philadelphia VA Medical Center, and Division of Rheumatology, and Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania; J.M. Von Feldt, MD, MSEd, Division of Rheumatology, Philadelphia VA Medical Center, and Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania; S. Mostoufi-Moab, MD, MSCE, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania; W. Kim, MD, Department of Radiology, Perelman School of Medicine, University of Pennsylvania; E. Taratuta, MD, Department of Radiology, Perelman School of Medicine, University of Pennsylvania; M.B. Leonard, MD, MSCE, Department of Pediatrics and Medicine, Stanford University. bakerjo@uphs.upenn.edu.
Joan Marie Von FeldtFrom the Division of Rheumatology, Philadelphia Veteran Affairs (VA) Medical Center; Division of Rheumatology, and Department of Biostatistics and Epidemiology, and Children's Hospital of Philadelphia, Department of Pediatrics, and Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Pediatrics and Medicine, Stanford University, Stanford, California, USA.J.F. Baker, MD, MSCE, Division of Rheumatology, Philadelphia VA Medical Center, and Division of Rheumatology, and Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania; J.M. Von Feldt, MD, MSEd, Division of Rheumatology, Philadelphia VA Medical Center, and Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania; S. Mostoufi-Moab, MD, MSCE, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania; W. Kim, MD, Department of Radiology, Perelman School of Medicine, University of Pennsylvania; E. Taratuta, MD, Department of Radiology, Perelman School of Medicine, University of Pennsylvania; M.B. Leonard, MD, MSCE, Department of Pediatrics and Medicine, Stanford University.
Sogol Mostoufi-MoabFrom the Division of Rheumatology, Philadelphia Veteran Affairs (VA) Medical Center; Division of Rheumatology, and Department of Biostatistics and Epidemiology, and Children's Hospital of Philadelphia, Department of Pediatrics, and Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Pediatrics and Medicine, Stanford University, Stanford, California, USA.J.F. Baker, MD, MSCE, Division of Rheumatology, Philadelphia VA Medical Center, and Division of Rheumatology, and Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania; J.M. Von Feldt, MD, MSEd, Division of Rheumatology, Philadelphia VA Medical Center, and Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania; S. Mostoufi-Moab, MD, MSCE, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania; W. Kim, MD, Department of Radiology, Perelman School of Medicine, University of Pennsylvania; E. Taratuta, MD, Department of Radiology, Perelman School of Medicine, University of Pennsylvania; M.B. Leonard, MD, MSCE, Department of Pediatrics and Medicine, Stanford University.
Woojin KimFrom the Division of Rheumatology, Philadelphia Veteran Affairs (VA) Medical Center; Division of Rheumatology, and Department of Biostatistics and Epidemiology, and Children's Hospital of Philadelphia, Department of Pediatrics, and Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Pediatrics and Medicine, Stanford University, Stanford, California, USA.J.F. Baker, MD, MSCE, Division of Rheumatology, Philadelphia VA Medical Center, and Division of Rheumatology, and Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania; J.M. Von Feldt, MD, MSEd, Division of Rheumatology, Philadelphia VA Medical Center, and Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania; S. Mostoufi-Moab, MD, MSCE, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania; W. Kim, MD, Department of Radiology, Perelman School of Medicine, University of Pennsylvania; E. Taratuta, MD, Department of Radiology, Perelman School of Medicine, University of Pennsylvania; M.B. Leonard, MD, MSCE, Department of Pediatrics and Medicine, Stanford University.
Elena TaratutaFrom the Division of Rheumatology, Philadelphia Veteran Affairs (VA) Medical Center; Division of Rheumatology, and Department of Biostatistics and Epidemiology, and Children's Hospital of Philadelphia, Department of Pediatrics, and Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Pediatrics and Medicine, Stanford University, Stanford, California, USA.J.F. Baker, MD, MSCE, Division of Rheumatology, Philadelphia VA Medical Center, and Division of Rheumatology, and Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania; J.M. Von Feldt, MD, MSEd, Division of Rheumatology, Philadelphia VA Medical Center, and Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania; S. Mostoufi-Moab, MD, MSCE, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania; W. Kim, MD, Department of Radiology, Perelman School of Medicine, University of Pennsylvania; E. Taratuta, MD, Department of Radiology, Perelman School of Medicine, University of Pennsylvania; M.B. Leonard, MD, MSCE, Department of Pediatrics and Medicine, Stanford University.
Mary B LeonardFrom the Division of Rheumatology, Philadelphia Veteran Affairs (VA) Medical Center; Division of Rheumatology, and Department of Biostatistics and Epidemiology, and Children's Hospital of Philadelphia, Department of Pediatrics, and Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Pediatrics and Medicine, Stanford University, Stanford, California, USA.J.F. Baker, MD, MSCE, Division of Rheumatology, Philadelphia VA Medical Center, and Division of Rheumatology, and Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania; J.M. Von Feldt, MD, MSEd, Division of Rheumatology, Philadelphia VA Medical Center, and Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania; S. Mostoufi-Moab, MD, MSCE, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania; W. Kim, MD, Department of Radiology, Perelman School of Medicine, University of Pennsylvania; E. Taratuta, MD, Department of Radiology, Perelman School of Medicine, University of Pennsylvania; M.B. Leonard, MD, MSCE, Department of Pediatrics and Medicine, Stanford University.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4M
Structural Bone Disease in Chronic Renal InsufficiencyR01DK064966 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI LEONARD, MARY BETH · 2003 to 2007
$2.7M
Patient Oriented Research in Vitamin D Deficiency in CKDK24DK076808 · NIDDK · STANFORD UNIVERSITY · PI LEONARD, MARY BETH · 2007 to 2016
$1.7M
Bone Deficits and Excess Adiposity after Pediatric Bone Marrow TransplantationK07CA166177 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI MOSTOUFI-MOAB, SOGOL · 2013 to 2017
$825k
Body composition, bone structure, and joint damage in rheumatoid arthritisIK2CX000955 · VA · PHILADELPHIA VA MEDICAL CENTER · PI BAKER, JOSHUA F. · 2013 to 2017
–
CSRD VA IK2 CX000955Intramural VA VA999999NCI NIH HHS K07 CA166177NCRR NIH HHS UL1 RR024134NIDDK NIH HHS K24 DK076808NIDDK NIH HHS R01 DK064966
6 · The paper itself

Abstract

objectiveRheumatoid arthritis (RA) is associated with low muscle mass and density. The objective of our study was to evaluate associations between 2 serum biomarkers [insulin-like growth factor 1 (IGF-1) and adiponectin] and skeletal muscle in RA.

methodsWhole-body dual energy X-ray absorptiometry measures of the appendicular lean mass index (ALMI; kg/m(2)) and total fat mass index (kg/m(2)), as well as the peripheral quantitative computed tomography measures of the lower leg muscle and fat cross-sectional area (CSA; cm(2)) and muscle density (an index of fat infiltration) were obtained from 50 participants with RA, ages 18-70 years. Multivariable linear regression analyses evaluated associations between body composition and levels of adiponectin and IGF-1, adjusted for age, sex, and adiposity.

resultsGreater age was associated with higher adiponectin (p = 0.06) and lower IGF-1 (p = 0.004). Eight subjects had IGF-1 levels below the reference range for their age and sex. These subjects had significantly lower ALMI and muscle CSA in multivariable models. Lower IGF-1 levels were associated with greater clinical disease activity and severity, as well as low ALMI, muscle CSA, and muscle density (defined as 1 SD below normative mean). After adjusting for age and sex, greater adiponectin levels were associated with lower BMI (p = 0.02) as well as lower ALMI, and lower muscle CSA, independent of adiposity (p < 0.05). Only greater Health Assessment Questionnaire scores were significantly associated with lower adiponectin levels.

conclusionLow IGF-1 and greater adiponectin levels are associated with lower muscle mass in RA. Lower IGF-1 levels were seen in subjects with greater disease activity and severity.

Indexed as

Body Mass IndexAbsorptiometry, PhotonAdiponectinAdolescentAdultAgedAge FactorsAntirheumatic AgentsArthritis, RheumatoidBiomarkersBody CompositionCohort StudiesFemaleHumansInsulin-Like Growth Factor ILinear ModelsAdiponectinAntirheumatic AgentsBiomarkersInsulin-Like Growth Factor IADIPONECTINCACHEXIALEAN MASSRHEUMATOID ARTHRITIS

Identifiers

PMID26329340
PMCPMC4809051
OpenAlexW2172747702

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.