Evidence map›Paper›PMID 26328787›Full record

Trial reportEuropean journal of pediatrics2016

Feasibility of monitoring stress using skin conduction measurements during intubation of newborns.

Robin van der Lee, Liesbeth J M Groot Jebbink, Thea H M van Herpen, Esther J d'Haens, Josette Bierhuizen, Richard A van Lingen

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Biomarkers for assessing pain and pain relief in the neonatal intensive care unit.Frontiers in pain research (Lausanne, Switzerland) · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Robin van der LeePrincess Amalia Department of Paediatrics, Department of Neonatology, Isala Clinics, Dokter van Heesweg 2, 8025 AB, Zwolle, The Netherlands. R.vanderlee@amc.nl.
Liesbeth J M Groot JebbinkPrincess Amalia Department of Paediatrics, Department of Neonatology, Isala Clinics, Dokter van Heesweg 2, 8025 AB, Zwolle, The Netherlands. l.j.groot.jebbink@isala.nl.
Thea H M van HerpenHospital Pharmacy, Isala Clinics, Zwolle, The Netherlands. t.h.m.herpen@isala.nl.
Esther J d'HaensPrincess Amalia Department of Paediatrics, Department of Neonatology, Isala Clinics, Dokter van Heesweg 2, 8025 AB, Zwolle, The Netherlands. e.j.haens@isala.nl.
Josette BierhuizenPrincess Amalia Department of Paediatrics, Department of Neonatology, Isala Clinics, Dokter van Heesweg 2, 8025 AB, Zwolle, The Netherlands. j.bierhuizen@isala.nl.
Richard A van LingenPrincess Amalia Department of Paediatrics, Department of Neonatology, Isala Clinics, Dokter van Heesweg 2, 8025 AB, Zwolle, The Netherlands. r.a.van.lingen@isala.nl.
Amalia Kinderziekenhuis · NLIsala · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to assess the feasibility of monitoring stress responses in newborns during naso-tracheal intubation after two different premedication regimens, using skin conductance measurements (SCM). Twenty-two newborns were randomised and premedicated with morphine + vecuronium or propofol. SCM (peaks/s) were collected prior to, during and after the procedure. Threshold for interpreting responses as stressful was 0.21 peaks/s. Intubation conditions and physiological parameters were registered. Intubation conditions were good in all newborns. Administration of morphine (range 1.4-10.3 min) before administration of vecuronium did not affect SCM when a stressful stimulus was applied. Within 1.6 min (range 0.8-3 min) after administration of vecuronium, SCM disappeared in 10 of 11 newborns. Propofol reduced SCM in 10 of 11 newborns at the first attempt. Further attempts were associated with increasing SCM, mostly above a threshold of 0.21 peaks/s. There were no significant changes in physiological parameters during the procedure for either premedication regimen.

conclusionThe variation in SCM between individual newborns limits the usefulness of SCM as stress monitor during intubation. The use of neuromuscular blockers for premedication precludes monitoring of SCM completely in newborns. WHAT IS KNOWN: Skin conductance measurements have been used successfully to monitor pain in awake newborn infants. WHAT IS NEW: Premedicated newborns display significant interindividual variation in skin conductance measurements during an intubation procedure. Neuromuscular blockade causes skin conductance measurements to disappear completely.

Indexed as

Galvanic Skin ResponseIntubation, IntratrachealStress, PhysiologicalAnesthetics, CombinedAnesthetics, IntravenousDeep SedationFeasibility StudiesHumansInfantInfant, NewbornMonitoring, PhysiologicMorphinePainPremedicationPropofolVecuronium BromideAnesthetics, CombinedAnesthetics, IntravenousMorphinePropofolVecuronium BromideDeep sedationGalvanic skin responseNeuromuscular blockade

Identifiers

PMID26328787
PMCPMC4724365
OpenAlexW1933506920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.