ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015
Mitochondrial DNA Heteroplasmy Associations With Neurosensory and Mobility Function in Elderly Adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speed.GeroScience · 2018Pooled it
- Associations of Blood Mitochondrial DNA Quality and Quantity with Risk of Kidney Function Decline.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Mitochondrial haplogroups, but not heteroplasmy, are associated with midlife cognitive function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Advances in research on propofol-induced postoperative cognitive dysfunction via Piezo channels.Frontiers in molecular neuroscience · 2025Review
- Unraveling the role and mechanism of mitochondria in postoperative cognitive dysfunction: a narrative review.Journal of neuroinflammation · 2024Review
- Joint and Individual Mitochondrial DNA Variation and Cognitive Outcomes in Black and White Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Mitochondria: A Potential Rejuvenation Tool against Aging.Aging and disease · 2024Review
- Molecular Damage in Aging.Nature aging · 2021Review
- Incident dementia and faster rates of cognitive decline are associated with worse multisensory function summary scores.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Multiple Sensory Impairment Is Associated With Increased Risk of Dementia Among Black and White Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Mitochondrial DNA Sequence Variants Associated With Blood Pressure Among 2 Cohorts of Older Adults.Journal of the American Heart Association · 2018Article
- Workshop on Synergies Between Alzheimer's Research and Clinical Gerontology and Geriatrics: Current Status and Future Directions.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Review
- Mitochondrial DNA m.3243A > G heteroplasmy affects multiple aging phenotypes and risk of mortality.Scientific reports · 2018Article
- Digital PCR Quantitation of Muscle Mitochondrial DNA: Age, Fiber Type, and Mutation-Induced Changes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health.Redox biology · 2016Article
- A synopsis on aging-Theories, mechanisms and future prospects.Ageing research reviews · 2016Review
- Mitophagy plays a central role in mitochondrial ageing.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
backgroundMitochondrial DNA (mtDNA) heteroplasmy is a mixture of normal and mutated mtDNA molecules in a cell. High levels of heteroplasmy at specific mtDNA sites lead to inherited mitochondrial diseases with neurological, sensory, and movement impairments. Here we test the hypothesis that heteroplasmy levels in elderly adults are associated with impaired function resembling mild forms of mitochondrial disease.
methodsWe examined platelet mtDNA heteroplasmy at 20 disease-causing sites for associations with neurosensory and mobility function among 137 participants from the community-based Health, Aging, and Body Composition Study.
resultsElevated mtDNA heteroplasmy at four mtDNA sites in complex I and tRNA genes was nominally associated with reduced cognition, vision, hearing, and mobility: m.10158T>C with Modified Mini-Mental State Examination score (p = .009); m.11778G>A with contrast sensitivity (p = .02); m.7445A>G with high-frequency hearing (p = .047); and m.5703G>A with 400 m walking speed (p = .007).
conclusionsThese results indicate that increased mtDNA heteroplasmy at disease-causing sites is associated with neurosensory and mobility function in older persons. We propose the novel use of mtDNA heteroplasmy as a simple, noninvasive predictor of age-related neurologic, sensory, and movement impairments.
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