ArticleJournal of mathematical biology2016
An investigation of the influence of extracellular matrix anisotropy and cell-matrix interactions on tissue architecture.
Article in Journal of mathematical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 37 citations in OpenAlex.
- Multiscale modelling shows how cell-ECM interactions impact ECM fibre alignment and cell detachment.PLoS computational biology · 2025Article
- A two-phase thin-film model for cell-induced gel contraction incorporating osmotic effects.Journal of mathematical biology · 2024Article
- A mathematical model for cell-induced gel contraction incorporating osmotic effects.Journal of mathematical biology · 2022Article
- Understanding and utilizing textile-based electrostatic flocking for biomedical applications.Applied physics reviews · 2021Review
- Mathematical simulation and prediction of tumor volume using RBF artificial neural network at different circumstances in the tumor microenvironment.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2021Article
- Impact of type-1 collagen hydrogel density on integrin-linked morphogenic response of SH-SY5Y neuronal cells.RSC advances · 2021Article
- The Impact of Elastic Deformations of the Extracellular Matrix on Cell Migration.Bulletin of mathematical biology · 2020Article
- Oriented suspension mechanics with application to improving flow linear dichroism spectroscopy.Proceedings. Mathematical, physical, and engineering sciences · 2019Article
- Influences of transversely isotropic rheology and translational diffusion on the stability of active suspensions.Royal Society open science · 2018Article
- Cell Contractility Facilitates Alignment of Cells and Tissues to Static Uniaxial Stretch.Biophysical journal · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanical interactions between cells and the fibrous extracellular matrix (ECM) in which they reside play a key role in tissue development. Mechanical cues from the environment (such as stress, strain and fibre orientation) regulate a range of cell behaviours, including proliferation, differentiation and motility. In turn, the ECM structure is affected by cells exerting forces on the matrix which result in deformation and fibre realignment. In this paper we develop a mathematical model to investigate this mechanical feedback between cells and the ECM. We consider a three-phase mixture of collagen, culture medium and cells, and formulate a system of partial differential equations which represents conservation of mass and momentum for each phase. This modelling framework takes into account the anisotropic mechanical properties of the collagen gel arising from its fibrous microstructure. We also propose a cell-collagen interaction force which depends upon fibre orientation and collagen density. We use a combination of numerical and analytical techniques to study the influence of cell-ECM interactions on pattern formation in tissues. Our results illustrate the wide range of structures which may be formed, and how those that emerge depend upon the importance of cell-ECM interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.