ArticleAmerican journal of cancer research2015
Analysis of difference of association between polymorphisms in the XRCC5, RPA3 and RTEL1 genes and glioma, astrocytoma and glioblastoma.
Article in American journal of cancer research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Effects of the MAML2 genetic variants in glioma susceptibility and prognosis.Bioscience reports · 2019Trial
- Integrated analysis of single-cell RNA-seq and spatial transcriptomics to identify the lactylation-related protein TUBB2A as a potential biomarker for glioblastoma in cancer cells by machine learning.Frontiers in immunology · 2025Article
- Article
- Exome sequencing in extreme altitude mountaineers identifies pathogenic variants in RTEL1 and COL6A1 previously associated with respiratory failure.Physiological reports · 2024Article
- RTEL1 gene polymorphisms and neuroblastoma risk in Chinese children.BMC cancer · 2023Article
- Impact ofPharmacogenomics and personalized medicine · 2023Article
- ARRDC3 polymorphisms may affect the risk of glioma in Chinese Han.Functional & integrative genomics · 2022Article
- In Defense of the Indefensible: A Very Naïve Approach to High-Dimensional Inference.Statistical science : a review journal of the Institute of Mathematical Statistics · 2021Article
- XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi-center study.Cancer medicine · 2021Article
- GOLGA7 rs11337, a Polymorphism at the MicroRNA Binding Site, Is Associated with Glioma Prognosis.Molecular therapy. Nucleic acids · 2019Article
- LPP and RYR2 Gene Polymorphisms Correlate with the Risk and the Prognosis of Astrocytoma.Journal of molecular neuroscience : MN · 2019Article
- Impact of AKAP6 polymorphisms on Glioma susceptibility and prognosis.BMC neurology · 2019Article
- Genetic analysis of the relation of telomere length-related gene (RTEL1) and coronary heart disease risk.Molecular genetics & genomic medicine · 2019Article
- Impact of ANXA5 polymorphisms on glioma risk and patient prognosis.Journal of neuro-oncology · 2019Article
- Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population.PloS one · 2018Article
- Association between regulator of telomere elongation helicase1 (RTEL1) gene and HAPE risk: A case-control study.Medicine · 2017Article
- Clinical and Molecular Heterogeneity of RTEL1 Deficiency.Frontiers in immunology · 2017Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGliomas are the most common aggressive brain tumors and have many complex pathological types. Previous reports have discovered that genetic mutations are associated with the risk of glioma. However, it is unclear whether uniform genetic mutations exist difference between glioma and its two pathological types in the Han Chinese population. MATERIALS AND
methodsWe evaluated 20 SNPs of 703 glioma cases (338 astrocytoma cases, 122 glioblastoma cases) and 635 controls in a Han Chinese population using χ(2) test and genetic model analysis.
resultsIn three case-control studies, we found rs9288516 in XRCC5 gene showed a decreased risk of glioma (OR, 0.85; 95% CI, 0.73-0.99; P = 0.042) and glioblastoma (OR, 0.70; 95% CI, 0.52-0.92; P = 0.001) in the allele model. We identified rs414805 in RPA3 gene showed an increased risk of glioblastoma in allele model (OR, 1.38; 95% CI, 1.00-1.89; P = 0.047) and dominant model (OR, 1.57; 95% CI, 1.05-2.35; P = 0.027), analysis respectively. Meanwhile, rs2297440 in RTEL1 gene showed an increased risk of glioma (OR, 1.30; 95% CI, 1.10-1.54; P = 0.002) and astrocytoma (OR, 1.26; 95% CI, 1.02-1.54; P = 0.029) in the allele model. In addition, we also observed a haplotype of "GCT" in the RTEL1 gene with an increased risk of astrocytoma (P = 0.005).
conclusionsPolymorphisms in the XRCC5, RPA3 and RTEL1 genes, combinating with previous reaserches, are associated with glioma developing. However, those genes mutations may play different roles in the glioma, astrocytoma and glioblastoma, respectively.
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