Evidence map›Paper›PMID 26328237›Full record

ArticleGeriatric orthopaedic surgery & rehabilitation2015

Is Scheduled Intravenous Acetaminophen Effective in the Pain Management Protocol of Geriatric Hip Fractures?

Alexander J Bollinger, Paul D Butler, Matthew S Nies, Debra L Sietsema, Clifford B Jones, Terrence J Endres

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Geriatric orthopaedic surgery & rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03198871 (Role of Scheduled Intravenous Acetaminophen for Postoperative Pain Management in an Enhanced Recovery After Surgery), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03198871 phase4completednot on this mapstarted 2018, after this paper: background citation

Role of Scheduled Intravenous Acetaminophen for Postoperative Pain Management in an Enhanced Recovery After Surgery (ERAS) Population: A Prospective, Randomized, Double-Blind and Placebo-Controlled Clinical Trial

TypeinterventionalSponsorKathirvel SubramaniamRan2018 to 2020Enrolled180ConditionsAbdominal Wall Hernia, Pancreatic Diseases, Bowel Disease, Gastric DiseaseArmsAcetaminophen Injectable Product, Sodium Chloride 0.9%, Intravenous
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Transdermal Buprenorphine for Pain Management Following a Neck of Femur Fracture.Geriatric orthopaedic surgery & rehabilitation · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Alexander J BollingerGrand Rapids Medical Education Partners, Department of Orthopaedic Surgery, Grand Rapids, MI, USA ; Michigan State University College of Human Medicine, Grand Rapids, MI, USA.
Paul D ButlerGrand Rapids Medical Education Partners, Department of Orthopaedic Surgery, Grand Rapids, MI, USA ; Michigan State University College of Human Medicine, Grand Rapids, MI, USA.
Matthew S NiesDepartment of Orthopaedic Surgery, University of Wisconsin, Madison, WI, USA.
Debra L SietsemaMichigan State University College of Human Medicine, Grand Rapids, MI, USA ; Orthopaedic Associates of Michigan, Grand Rapids, MI, USA.
Clifford B JonesMichigan State University College of Human Medicine, Grand Rapids, MI, USA ; Orthopaedic Associates of Michigan, Grand Rapids, MI, USA.
Terrence J EndresMichigan State University College of Human Medicine, Grand Rapids, MI, USA ; Orthopaedic Associates of Michigan, Grand Rapids, MI, USA.
Michigan State University · USOrthopaedic Associates of Michigan · USGrand Rapids Community College · USUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHip fractures have significant effects on the geriatric population and the health care system. Prior studies have demonstrated both the safety of intravenous (IV) acetaminophen and its efficacy in decreasing perioperative narcotic consumption. The purpose of this study is to evaluate the effect of scheduled IV acetaminophen for perioperative pain control on length of hospital stay, pain level, narcotic use, rate of missed physical therapy (PT) sessions, adverse effects, and discharge disposition in geriatric patients with hip fractures.

methodsA retrospective review was performed of all patients 65 years and older admitted to a level I trauma center, who received operative treatment for a hip fracture over a 2-year period. Demographic data, in-hospital variables, and outcome measures were analyzed. Three hundred thirty-six consecutive fractures in 332 patients met inclusion criteria. These patients were divided into 2 cohorts. Group 1 (169 fractures) consisted of patients treated before the initiation of a standardized IV acetaminophen perioperative pain control protocol, and group 2 (167 fractures) consisted of those treated after the protocol was initiated.

resultsGroup 2 had a statistically significant shorter mean length of hospital stay (4.4 vs 3.8 days), lower mean pain score (4.2 vs 2.8), lower mean narcotic usage (41.3 vs 28.3 mg), lower rate of PT sessions missed (21.8% vs 10.4%), and higher likelihood of discharge home (7% vs 19%; P ≤ .001). Use of IV acetaminophen was also consistently and independently predictive of the same variables (P < .01).

conclusionThe utilization of scheduled IV acetaminophen as part of a standardized pain management protocol for geriatric hip fractures resulted in shortened length of hospital stay, decreased pain levels and narcotic use, fewer missed PT sessions, and higher rate of discharge to home. LEVEL OF EVIDENCE: Therapeutic level III.

Indexed as

acetaminophengeriatric hip fracturelength of stayperioperative pain

Identifiers

PMID26328237
PMCPMC4536513
OpenAlexW2149787162

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.