Evidence map›Paper›PMID 26328230›Full record

ArticleGeriatric orthopaedic surgery & rehabilitation2015

Efficacy of Blood Flow-Restricted Low-Load Resistance Training For Quadriceps Strengthening in Men at Risk of Symptomatic Knee Osteoarthritis.

Neil Segal, Maria D Davis, Alan E Mikesky

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Geriatric orthopaedic surgery & rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 9 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 9 syntheses or guidelines pooled it, 90 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Neil SegalDepartment of Rehabilitation Medicine, University of Kansas, Kansas City, KS, USA.
Maria D DavisDepartment of Orthopaedics & Rehabilitation, University of Iowa, Iowa City, IA, USA.
Alan E MikeskyDepartment of Kinesiology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
Indiana University – Purdue University Indianapolis · USUniversity of Iowa · USUniversity of Kansas · US

Funding

Optimizing Mobility in Elders with Knee Osteoarthritis: Gait and Power TrainingK23AG030945 · NIA · UNIVERSITY OF IOWA · PI SEGAL, NEIL A · 2007 to 2011
$862k
NIA NIH HHS K23 AG030945
6 · The paper itself

Abstract

backgroundGreater quadriceps strength has been associated with lower risk of symptomatic knee osteoarthritis (OA) in older adults. However, factors that confer elevated risk of knee OA (eg, sedentary lifestyle, obesity, and knee injury) also contribute to a reduced tolerance of resistance training programs at ≥60% 1-repetition maximum (1RM). Therefore, the current study assessed whether concurrent application of blood flow restriction (BFR) to low-load resistance training is an efficacious and tolerable means of improving quadriceps strength in men at risk of symptomatic knee OA.

methodsMen older than age 45, with a history of knee injury or elevated body mass index (BMI), were randomized to low-load resistance training (30% 1RM) either with or without concurrent BFR. Isotonic double-leg press strength and isokinetic knee extensor strength were assessed before and after 4 weeks of training 3 times/wk. Knee pain (Knee Osteoarthritis Outcome Score) was assessed for tolerance.

resultsOf the 42 men (mean age 56.1 ± 7.7 years) who were randomized, 41 completed the program. There were no significant intergroup differences in age, BMI, knee pathology, or muscle strength at baseline. Although leg press 1RM improved in both control and BFR groups, there were no significant intergroup differences in primary or secondary measures of muscle strength. The BFR was not associated with worsening of knee pain, but there was a significant improvement in knee pain in the control group.

conclusionsIn comparison with training without BFR, addition of BFR to 30% 1RM resistance training for 4 weeks did not confer significantly greater increases in leg press or quadriceps strength in older men with risk factors for symptomatic knee OA.

Indexed as

blood flow restrictionmuscle strengthquadriceps musclerehabilitationresistance training

Identifiers

PMID26328230
PMCPMC4536503
OpenAlexW2319699376

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.