ArticleAmerican journal of translational research2015
Characterization of Der f 29, a new allergen from dermatophagoides farinae.
Article in American journal of translational research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Structure/epitope analysis and IgE binding activities of three cyclophilin family proteins from Dermatophagoides pteronyssinus.Scientific reports · 2023Article
- Exploration of the effect of probiotics supplementation on intestinal microbiota of food allergic mice.American journal of translational research · 2017Article
- Role of Predatory Mites in Persistent Nonoccupational Allergic Rhinitis.Canadian respiratory journal · 2016Article
- Thiol peroxiredoxin, a novel allergen fromAmerican journal of translational research · 2016Article
- Characterization of arginine kinase, anovel allergen of dermatophagoides farinae (Der f 20).American journal of translational research · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
More than 30 allergens have been identified from Dermatophagoides farina (D. farina), which is one of the main species of house dust mites. The mite allergens are an important factor contributing to allergic disease in the world. As the detection and identification of new allergens is critical for the diagnosis or treatment of allergic diseases, we sought to characterize the profilin of D. farina (Der f 29) in this study. The results showed that 21% of allergic patients displayed positive results in skin prick test with recombinant Der f 29 (rDer f 29) as the specific allergen; specific IgE reactivity to rDer f 29 was shown by Western Blot and ELISA. In addition, rDer f 29 induced bone marrow-derived dendritic cells (DC) to produce T cells immunoglobulin domain and mucin domain protein 4 (TIM4). Moreover, an allergic asthma mouse model was established by challenging with rDer f 29. Airway hyperresponsiveness, serum specific IgE, IgG1, eosinophil infiltration in the allergic mice bronchoalveolar lavage fluid, the cytokines interleukin-4 (IL-4) and interferon-γ (INF-γ) from spleen cells were markedly increased; the histology showed severe inflammation in the lung. In conclusion, Der f 29 is identified as a new type of the house dust mite allergen.
Indexed as
Identifiers
26328014PMC4548322W1531831745What OpenQuestion holds
Registered trials
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