Evidence map›Paper›PMID 26328004›Full record

ReviewAmerican journal of translational research2015

Plant-derived neuroprotective agents in Parkinson's disease.

Wenyu Fu, Wenxin Zhuang, Shuanhu Zhou, Xin Wang

Open access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in American journal of translational research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 97 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Review
  7. Review
  8. aSynPEP-DB: a database of biogenic peptides for inhibiting α-synuclein aggregation.Database : the journal of biological databases and curation · 2023
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Ferulic Acid Exerts Neuroprotective Effects via Autophagy Induction inOxidative medicine and cellular longevity · 2022
    Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Wenyu FuHistology and Embryology, Weifang Medical University Weifang, Shandong, P R China.
Wenxin ZhuangMedical Research Center, Weifang Medical University Weifang, Shandong, P R China.
Shuanhu ZhouDepartment of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School Massachusetts 02115, USA.
Xin WangDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School Massachusetts 02115, USA.
Brigham and Women's Hospital · USWeifang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is one of the most common degenerative disorders of the central nervous system among the elderly. The disease is caused by the slow deterioration of the dopaminergic neurons in the substantia nigra. Treatment strategies to protect dopaminergic neurons from progressive damage have received much attention. However there is no effective treatment for PD. Traditional Chinese medicines have shown potential clinical efficacy in attenuating the progression of PD. Increasing evidence indicates that constituents of some Chinese herbs include resveratrol, curcumin, and ginsenoside can be neuroprotective. Since pathologic processes in PD including inflammation, oxidative stress, apoptosis, mitochondrial dysfunction, and genetic factors lead to neuronal degeneration, and these Chinese herbs can protect dopaminergic neurons from neuronal degeneration, in this article, we review the neuroprotective roles of these herbs and summarize their anti-inflammatory, antioxidant, and anti-apoptotic effects in PD. In addition, we discuss their possible mechanisms of action in in vivo and in vitro models of PD. Traditional Chinese medicinal herbs, with their low toxicity and side-effects, have become the potential therapeutic interventions for prevention and treatment of PD and other neurodegenerative diseases.

Indexed as

Chinese herbscurcuminginsenosideneuroprotectionParkinson’s diseaseresveratrol

Identifiers

PMID26328004
PMCPMC4548312
OpenAlexW1662005430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.