ArticlePrzeglad menopauzalny = Menopause review2014
Proinflammatory and anti-inflammatory cytokine changes related to menopause.
Article in Przeglad menopauzalny = Menopause review, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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Who cites it
60 citing papers in PubMed, 113 citations in OpenAlex.
- Adipocytokine plasma level changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women.European journal of nutrition · 2023Trial
- Bioactive Yoghurt Containing Curcumin and Chlorogenic Acid Reduces Inflammation in Postmenopausal Women.Nutrients · 2022Trial
- Inflammatory marker changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women.Scientific reports · 2020Trial
- The Effect of Habitual Fat Intake, IL6 Polymorphism, and Different Diet Strategies on Inflammation in Postmenopausal Women with Central Obesity.Nutrients · 2019Trial
- Association of serum cytokines with oral HPV clearance.Cytokine · 2016Trial
- Estrogen Withdrawal-Induced Cognitive Impairment in Menopausal Women: Mechanisms and Prospects for Integrated Interventions.International journal of molecular sciences · 2026Review
- Impact of Menopause and Clinical Considerations in Patients With Inflammatory Bowel Disease.Gastroenterology & hepatology · 2026Article
- The Impact of Estradiol Dynamics During the Menopause Transition on Depression Risk: A Narrative Review of Estradiol's Neurobiological Mechanisms.Biological psychiatry · 2026Review
- Menopause influences lung inflammatory response and miRNA expression in brain death donors.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Association between De Ritis ratio and mortality in individuals with diabetes or prediabetes: evidence from NHANES (1999-2018).European journal of medical research · 2025Article
- Interactions among tumor subtype, PPARγ expression, and adipose proliferation shape outcomes in breast cancer.Physiological reports · 2025Article
- Serum GDF15 as a supportive biomarker in female fibromyalgia patients based on a prospective case-control study.Scientific reports · 2025Article
- The Hypothalamic-Pituitary-Ovarian Axis, Ovarian Disorders, and Brain Aging.Endocrinology · 2025Review
- Perimenopausal depression: Targeting inflammation and oxidative stress (Review).Molecular medicine reports · 2025Review
- Review
- Thymus Degeneration in Women and the Influence of Female Sexual Hormones on Thymic Epithelial Cells.International journal of molecular sciences · 2025Review
- The Impact of Menopause on Autoimmune and Rheumatic Diseases.Clinical reviews in allergy & immunology · 2025Review
- The role of dietary inflammation in the risk of osteoporosis in Iranian postmenopausal women: a case-control study.Scientific reports · 2025Article
- Reproductive aging in biological females: mechanisms and immediate consequences.Frontiers in endocrinology · 2025Review
- Transcriptomic analysis reveals the key role of inflammatory and immune signaling in the anti-perimenopausal depression effects of Bushen Shugan Huayu decoction.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
the aim of the studyThe aim of the study was to determine menopause-related changes in serum levels of main proinflammatory and anti-inflammatory cytokines. MATERIAL AND
methodsThe study included 175 women, who were divided into 5 study groups (group 1 - fertile women; group 2 - pre- and perimenopausal women; group 3 - postmenopausal women; group 4 - surgically induced menopausal women; group 5 - women with chronic inflammatory pathology). We evaluated the serum levels of interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-17, IL-20 and of the tumour necrosis factor (TNF)α with the use of two multiplex cytokine kits. We also determined the serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), 17β-estradiol (17β-E2), progesterone (P), dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) using sandwich ELISA.
resultsThe serum level of IL-1β, IL-8 and TNF-α in women with natural menopause and in women with surgically induced menopause is significantly higher than in fertile women in the control group. In patients with surgically induced menopause and in women with natural menopause, IL-8 serum levels are similar to those seen in patients with chronic inflammatory diseases. There is a statistically significant decrease in serum levels of IL-20 in women with natural or surgical menopause than in fertile and premenopausal women.
conclusionsWomen in menopause have elevated levels of the key proinflammatory cytokines, i.e. IL-1β, IL-8 and TNF-α and low serum levels of IL-20 in comparison with fertile women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.