ArticleWorld journal of gastroenterology2015
Distinctive roles of unsaturated and saturated fatty acids in hyperlipidemic pancreatitis.
Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Hypertriglyceridaemia-Associated Acute Pancreatitis: Pathophysiological Insights and Advances in Clinical Management.Biomedicines · 2026Review
- Beyond triglyceride clearance: rethinking hypertriglyceridemia-associated acute pancreatitis in the apoC-III era.Gastroenterology report · 2026Review
- Risk factors for disease severity in hypertriglyceridemic acute pancreatitis: a single-center retrospective study.BMC gastroenterology · 2026Article
- Perilla Seed Oil Alleviates High-Fat-Diet-Induced Hyperlipidemia by Regulating Fatty Acid Metabolism via the PI3K/Akt/NOS3 Pathway.Foods (Basel, Switzerland) · 2025Article
- Fatty acid analysis identifies an aberrant circulating triglyceride composition in patients with hypertriglyceridemia-induced acute pancreatitis.Scientific reports · 2025Article
- Induction of hyperlipidemic pancreatitis by different fatty acids: A narrative review.World journal of gastroenterology · 2025Review
- Integrating metagenomics with metabolomics for gut microbiota and metabolites profiling in acute pancreatitis.Scientific reports · 2024Article
- Long-chain fatty acids - The turning point between 'mild' and 'severe' acute pancreatitis.Heliyon · 2024Review
- Integrated global and unique metabolic characteristics to reveal the intervention effect of Yiyi decoction on acute pancreatitis.PloS one · 2024Article
- Evaluating the efficacy and timing of blood purification modalities in early-stage hyperlipidemic acute pancreatitis treatment.Lipids in health and disease · 2023Review
- Activation of AMPK ameliorates acute severe pancreatitis by suppressing pancreatic acinar cell necroptosis in obese mice models.Cell death discovery · 2023Article
- Intrapancreatic fat, pancreatitis, and pancreatic cancer.Cellular and molecular life sciences : CMLS · 2023Review
- Comprehensive review on the pathogenesis of hypertriglyceridaemia-associated acute pancreatitis.Annals of medicine · 2023Review
- Impact of fatty acid composition on markers of exocrine pancreatic stimulation in dogs.PloS one · 2023Article
- Hypertriglyceridemia Acute Pancreatitis: Animal Experiment Research.Digestive diseases and sciences · 2022Review
- Sleeve Gastrectomy Attenuates the Severity of Cerulein-Induced Acute Pancreatitis in Obese Rats.Obesity surgery · 2021Article
- The Truth About Fish (Oil) in the Treatment of Dyslipidemia.Current atherosclerosis reports · 2021Review
- Dietary Fat Patterns and Outcomes in Acute Pancreatitis in Spain.Frontiers in medicine · 2020Article
- Large triglyceride-rich lipoproteins in hypertriglyceridemia are associated with the severity of acute pancreatitis in experimental mice.Cell death & disease · 2019Article
- Association of the hypertriglyceridemic waist phenotype and severity of acute pancreatitis.Lipids in health and disease · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate how the saturated and unsaturated fatty acid composition influences the susceptibility of developing acute pancreatitis.
methodsPrimary pancreatic acinar cells were treated with low and high concentrations of different saturated and unsaturated fatty acids, and changes in the cytosolic Ca(2+) signal and the expression of protein kinase C (PKC) were measured after treatment.
resultsUnsaturated fatty acids at high concentrations, including oleic acid, linoleic acid, palmitoleic acid, docosahexaenoic acid, and arachidonic acid, induced a persistent rise in cytosolic Ca(2+) concentrations in acinar cells. Unsaturated fatty acids at low concentrations and saturated fatty acids, including palmitic acid, stearic acid, and triglycerides, at low and high concentrations were unable to induce a rise in Ca(2+) concentrations in acinar cells. Unsaturated fatty acids at high concentrations but not saturated fatty acids induced intra-acinar cell trypsin activation and cell damage and increased PKC expression.
conclusionAt sufficiently high concentrations, unsaturated fatty acids were able to induce acinar cells injury and promote the development of pancreatitis. Unsaturated fatty acids may play a distinctive role in the pathogenesis of pancreatitis through the activation of PKC family members.
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