Evidence map›Paper›PMID 26327213›Full record

ArticleOncotarget2015

Azathioprine induction of tumors with microsatellite instability: risk evaluation using a mouse model.

Sahra Bodo, Magali Svrcek, Isabelle Sourrouille, Peggy Cuillières-Dartigues, Tatiana Ledent, Sylvie Dumont, Laetitia Dinard, Philippe Lafitte, Camille Capel, Ada Collura and 10 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Genome instability and lymphoma.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
  3. Article
  4. Treatment-resistant atopic dermatitis: challenges and solutions.Clinical, cosmetic and investigational dermatology · 2019
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 1 country.

Sahra BodoINSERM, UMR_S 938, CDR Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, F-75012, Paris, France.
Magali SvrcekINSERM, UMR_S 938, CDR Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, F-75012, Paris, France.
Isabelle SourrouilleINSERM, UMR_S 938, CDR Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, F-75012, Paris, France.
Peggy Cuillières-DartiguesAP-HP, Institut Gustave Roussy, Service d'Anatomie Pathologique, F-94805 Villejuif, France.
Tatiana LedentINSERM, UMR_S 938, CDR Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, F-75012, Paris, France.
Sylvie DumontSorbonne Universités, UPMC Univ Paris 06, UMR_S 938, CDR Saint-Antoine, F-75012 Paris, France.
Laetitia DinardINSERM, UMR_S 938, CDR Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, F-75012, Paris, France.
Philippe LafitteINSERM, UMR_S 938, CDR Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, F-75012, Paris, France.
Camille CapelINSERM, UMR_S 938, CDR Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, F-75012, Paris, France.
Ada ColluraINSERM, UMR_S 938, CDR Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, F-75012, Paris, France.
Olivier BuhardINSERM, UMR_S 938, CDR Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, F-75012, Paris, France.
Kristell WanherdrickINSERM, UMR_S 938, CDR Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, F-75012, Paris, France.
Alexandra ChalastanisINSERM, UMR_S 938, CDR Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, F-75012, Paris, France.
Virginie Penard-LacroniqueINSERM, U985, Institut Gustave Roussy, F-94805 Villejuif, France.
Bettina FabianiAP-HP, Hôpital Saint-Antoine, Service d'Anatomie Pathologique, F-75012 Paris, France.
Jean-François FléjouINSERM, UMR_S 938, CDR Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, F-75012, Paris, France.
Nicole BrousseAP-HP, Hôpital Necker-Enfants Malades, Service d'Anatomie Pathologique, F-75015 Paris, France.
Laurent BeaugerieSorbonne Universités, UPMC Univ Paris 06, UMR_S 938, CDR Saint-Antoine, F-75012 Paris, France.
Alex DuvalINSERM, UMR_S 938, CDR Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, F-75012, Paris, France.
Martine MulerisINSERM, UMR_S 938, CDR Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, F-75012, Paris, France.
Sorbonne Université · FRCentre de Recherche Saint-Antoine · FRAssistance Publique – Hôpitaux de Paris · FRInserm · FRHôpital Saint-Antoine · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mismatch-repair (MMR)-deficient cells show increased in vitro tolerance to thiopurines because they escape apoptosis resulting from MMR-dependent signaling of drug-induced DNA damage. Prolonged treatment with immunosuppressants including azathioprine (Aza), a thiopurine prodrug, has been suggested as a risk factor for the development of late onset leukemias/lymphomas displaying a microsatellite instability (MSI) phenotype, the hallmark of a defective MMR system. We performed a dose effect study in mice to investigate the development of MSI lymphomas associated with long term Aza treatment. Over two years, Aza was administered to mice that were wild type, null or heterozygous for the MMR gene Msh2. Ciclosporin A, an immunosuppressant with an MMR-independent signaling, was also administered to Msh2(wt) mice as controls. Survival, lymphoma incidence and MSI tumor phenotype were investigated. Msh2(+/-) mice were found more tolerant than Msh2(wt) mice to the cytotoxicity of Aza. In Msh2(+/-) mice, Aza induced a high incidence of MSI lymphomas in a dose-dependent manner. In Msh2(wt) mice, a substantial lifespan was only observed at the lowest Aza dose. It was associated with the development of lymphomas, one of which displayed the MSI phenotype, unlike the CsA-induced lymphomas. Our findings define Aza as a risk factor for an MSI-driven lymphomagenesis process.

Indexed as

Microsatellite InstabilityAdultAgedAnimalsAzathioprineDisease Models, AnimalDNA Mismatch RepairDose-Response Relationship, DrugFemaleHumansImmunohistochemistryImmunosuppressive AgentsInflammatory Bowel DiseasesKaplan-Meier EstimateLymphomaMaleAzathioprineImmunosuppressive AgentsMsh2 protein, mouseMutS Homolog 2 Proteinazathioprineiatrogenic cancermicrosatellite instabilitypharmacogeneticsthiopurine tolerance

Identifiers

PMID26327213
PMCPMC4694807
OpenAlexW1892308208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.