ArticleBioanalysis2015
Cocaine and metabolite concentrations in DBS and venous blood after controlled intravenous cocaine administration.
Article in Bioanalysis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 30 citations in OpenAlex.
- Detection of 26 Drugs of Abuse and Metabolites in Quantitative Dried Blood Spots by Liquid Chromatography-Mass Spectrometry.Molecules (Basel, Switzerland) · 2024Article
- New Trend in Toxicological Screening Using Volumetric Absorptive Microsampling (VAMS) and High-Resolution Mass Spectrometry (HR/MS) Combination.Molecules (Basel, Switzerland) · 2023Article
- Current developments of bioanalytical sample preparation techniques in pharmaceuticals.Journal of pharmaceutical analysis · 2022Review
- Dried matrix spots: an evolving trend in the toxicological field.Forensic science, medicine, and pathology · 2022Review
- Discovery of donor age markers from bloodstain by LC-MS/MS using a metabolic approach.International journal of legal medicine · 2022Article
- Emerging trends in paper spray mass spectrometry: Microsampling, storage, direct analysis, and applications.Mass spectrometry reviews · 2020Review
- Virtual drug testing: redefining sample collection in a global pandemic.Bioanalysis · 2020Article
- Blood and Plasma Volumetric Absorptive Microsampling (VAMS) Coupled to LC-MS/MS for the Forensic Assessment of Cocaine Consumption.Molecules (Basel, Switzerland) · 2020Article
- Oral fluid cocaine and benzoylecgonine concentrations following controlled intravenous cocaine administration.Forensic science international · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundDBS are an increasingly common clinical matrix. METHODS &
resultsSensitive and specific methods for DBS and venous blood cocaine and metabolite detection by LC-HRMS and 2D GC-MS, respectively, were validated to examine correlation between concentrations following controlled intravenous cocaine administration. Linear ranges from 1 to 200 µg/l were achieved, with acceptable bias and imprecision. Authentic matched specimens' (392 DBS, 97 venous blood) cocaine and benzoylecgonine concentrations were qualitatively similar, but DBS had much greater variability (21.4-105.9 %CV) and were lower than in blood.
conclusionDBS offer advantages for monitoring cocaine intake; however, differences between capillary and venous blood and DBS concentration variability must be addressed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.