ArticleInvestigative ophthalmology & visual science2015
Mapping the 3D Connectivity of the Rat Inner Retinal Vascular Network Using OCT Angiography.
Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Evaluating Signs of Microangiopathy Secondary to Diabetes in Different Areas of the Retina with Swept Source OCTA.Investigative ophthalmology & visual science · 2020Trial
- Response of capillaries and small arterioles to full-field flicker is not dependent on local ganglion cell thickness.Biomedical optics express · 2025Article
- Light conditions influence optic nerve OCT angiography parameter in healthy subjects with neutral pupils.Scientific reports · 2023Article
- Optical Coherence Tomography Angiography of Volumetric Arteriovenous Relationships in the Healthy Macula and Their Derangement in Disease.Investigative ophthalmology & visual science · 2023Article
- Mapping the human parafoveal vascular network to understand flow variability in capillaries.PloS one · 2023Article
- In Vivo Imaging of Retinal and Choroidal Morphology and Vascular Plexuses of Vertebrates Using Swept-Source Optical Coherence Tomography.Translational vision science & technology · 2022Article
- Towards standardizing retinal optical coherence tomography angiography: a review.Light, science & applications · 2022Review
- Perspectives on diabetic retinopathy from advanced retinal vascular imaging.Eye (London, England) · 2022Review
- Scalable mapping of myelin and neuron density in the human brain with micrometer resolution.Scientific reports · 2022Article
- Visibility of microvessels in Optical Coherence Tomography angiography depends on angular orientation.Journal of biophotonics · 2020Article
- Vascular Density of Deep, Intermediate and Superficial Vascular Plexuses Are Differentially Affected by Diabetic Retinopathy Severity.Investigative ophthalmology & visual science · 2020Observational
- Imaging oxygenation of retinal capillaries with depth resolution.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Response of the Trilaminar Retinal Vessel Network to Intraocular Pressure Elevation in Rat Eyes.Investigative ophthalmology & visual science · 2020Article
- Clarification and confocal imaging of the nonhuman primate placental micro-anatomy.BioTechniques · 2019Article
- Hemodynamic Response of the Three Macular Capillary Plexuses in Dark Adaptation and Flicker Stimulation Using Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2019Article
- Rodent retinal circulation organization and oxygen metabolism revealed by visible-light optical coherence tomography.Biomedical optics express · 2018Article
- Human Parafoveal Capillary Vascular Anatomy and Connectivity Revealed by Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2018Observational
- Investigation of artifacts in retinal and choroidal OCT angiography with a contrast agent.Biomedical optics express · 2018Article
- High Resolution Ultrasound Superharmonic Perfusion Imaging: In Vivo Feasibility and Quantification of Dynamic Contrast-Enhanced Acoustic Angiography.Annals of biomedical engineering · 2017Article
- [Optical coherence tomography angiography (OCT‑A) in rats].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThe purpose of this study is to demonstrate three-dimensional (3D) graphing based on optical coherence tomography (OCT) angiography for characterization of the inner retinal vascular architecture and determination of its topologic principles.
methodsRat eyes (N = 3) were imaged with a 1300-nm spectral/Fourier domain OCT microscope. A topologic model of the inner retinal vascular network was obtained from OCT angiography data using a combination of automated and manually-guided image processing techniques. Using a resistive network model, with experimentally-quantified flow in major retinal vessels near the optic nerve head as boundary conditions, theoretical changes in the distribution of flow induced by vessel dilations were inferred.
resultsA topologically-representative 3D vectorized graph of the inner retinal vasculature, derived from OCT angiography data, is presented. The laminar and compartmental connectivity of the vasculature are characterized. In contrast to sparse connectivity between the superficial vitreal vasculature and capillary plexuses of the inner retina, connectivity between the two capillary plexus layers is dense. Simulated dilation of single arterioles is shown to produce both localized and lamina-specific changes in blood flow, while dilation of capillaries in a given retinal vascular layer is shown to lead to increased total flow in that layer.
conclusionsOur graphing and modeling data suggest that vascular architecture enables both local and lamina-specific control of blood flow in the inner retina. The imaging, graph analysis, and modeling approach presented here will help provide a detailed characterization of vascular changes in a variety of retinal diseases, both in experimental preclinical models and human subjects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.