Evidence map›Paper›PMID 26325362›Full record

ArticleJournal of women's health (2002)2015

Sex Differences Research, Precision Medicine, and the Future of Women's Health.

Virginia M Miller, Walter A Rocca, Stephanie S Faubion

Abstract read
In one paragraph

Article in Journal of women's health (2002), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Reporting of sex as a variable in cardiovascular studies using cultured cells: A systematic review.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Pooled it
  2. Review
  3. Article
  4. "Precision Medicine" and the Failed Search for Binary Brain Sex Differences to Address Gender Behavioral Health Disparities.American journal of human biology : the official journal of the Human Biology Council · 2025
    Review
  5. Small Extracellular Vesicles from Breast Cancer Cells Induce Cardiotoxicity.International journal of molecular sciences · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. One study at a time.Trauma surgery & acute care open · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Research on Women's Health: Ready for the Future.Journal of women's health (2002) · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Virginia M Miller1 Departments of Surgery and Physiology and Biomedical Engineering, Women's Health Clinic, Mayo Clinic , Rochester, Minnesota.
Walter A Rocca2 Departments of Health Sciences Research and Neurology, Women's Health Clinic, Mayo Clinic , Rochester, Minnesota.
Stephanie S Faubion3 Division of General Internal Medicine, Women's Health Clinic, Mayo Clinic , Rochester, Minnesota.

Funding

Sex-specific Risk for Vascular Dysfunction and Cognitive DeclineP50AG044170 · NIA · MAYO CLINIC ROCHESTER · PI MILLER, VIRGINIA M · 2012 to 2017
$6.1M
NIA NIH HHS P50 AG044170
6 · The paper itself

Abstract

The National Institutes of Health's (NIH) commitment to improving health outcomes for women and men through rigorous science has been compromised by the lack of basic science evidence obtained from female animals. To correct this limitation, in June 2015 the NIH announced expectations that "sex," as a biological variable, be included into research design and analysis in studies of vertebrate animals and humans (NOT-OD-15-102). Scientists must take the responsibility to implement this directive. However, in doing so, there is a risk that attention could be restricted to only studies of direct comparison between female/women and male/men. By contrast, understanding how sex influences health and disease needs to take a programmatic approach that includes the study of sex-specific conditions. A programmatic approach will assure the advancement of knowledge to improve women's health.

Indexed as

Precision MedicineSex CharacteristicsSex FactorsWomen's HealthAnimalsFemaleHumansMaleNational Institutes of Health (U.S.)Research DesignUnited States

Identifiers

PMID26325362
PMCPMC4683561

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.